Evidence map›Paper›PMID 31670611›Full record

ReviewPhysiological reviews2020

The Physiology of the Gastric Parietal Cell.

Amy C Engevik, Izumi Kaji, James R Goldenring

Open access · bronzeAbstract readReview
In one paragraph

Review in Physiological reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 270 citations in OpenAlex.

  1. Trial
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  9. Preoperative fasting guidelines: A narrative review.European journal of anaesthesiology and intensive care · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Transforming Treatment: The Impact of Bariatric Surgery on Oral Drug Absorption.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amy C EngevikDepartments of Surgery and of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Vanderbilt University Medical Center and the Nashville VA Medical Center, Nashville, Tennessee.
Izumi KajiDepartments of Surgery and of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Vanderbilt University Medical Center and the Nashville VA Medical Center, Nashville, Tennessee.
James R GoldenringDepartments of Surgery and of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Vanderbilt University Medical Center and the Nashville VA Medical Center, Nashville, Tennessee.
Nashville VA Medical Center · US

Funding

SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSAR01DK048370 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 1994 to 2025
$10.1M
Surgical Oncology Training GrantT32CA106183 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI James Richard Goldenring · 2004 to 2026
$6.0M
Induction and Evolution of Metaplasia in the StomachR01DK101332 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eunyoung Choi, James Richard Goldenring · 2014 to 2026
$5.9M
Molecular characteristics of the apical recycling systemR01DK070856 · NIDDK · VANDERBILT UNIVERSITY · PI GOLDENRING, JAMES RICHARD · 2006 to 2014
$3.1M
Deficits in Enterocyte Apical Transporters Associated with Loss of Myosin VbF32DK111101 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGEVIK, AMY C · 2016 to 2018
$113k
BLRD VA I01 BX000930NCI NIH HHS T32 CA106183NIDDK NIH HHS F32 DK111101NIDDK NIH HHS R01 DK048370NIDDK NIH HHS R01 DK070856NIDDK NIH HHS R01 DK101332
6 · The paper itself

Abstract

Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food, absorption of minerals, and control of harmful bacteria. However, a fine balance of activators and inhibitors of parietal cell-mediated acid secretion is required to ensure proper digestion of food, while preventing damage to the gastric and duodenal mucosa. As a result, parietal cell secretion is highly regulated through numerous mechanisms including the vagus nerve, gastrin, histamine, ghrelin, somatostatin, glucagon-like peptide 1, and other agonists and antagonists. The tight regulation of parietal cells ensures the proper secretion of HCl. The H

Indexed as

AnimalsCell ShapeGastric AcidH(+)-K(+)-Exchanging ATPaseHomeostasisHumansParietal Cells, GastricPotassiumProton Pump InhibitorsSecretory PathwaySignal TransductionH(+)-K(+)-Exchanging ATPasePotassiumProton Pump Inhibitorsacid secretiongrowth factorsmucosal homeostasisparietal cellstomach

Identifiers

PMID31670611
PMCPMC7327232
OpenAlexW2985640214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.