ArticleThe British journal of radiology2020
Image-guidance triggered adaptive replanning of radiation therapy for locally advanced lung cancer: an evaluation of cases requiring plan adaptation.
Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Offline Plan Adaptation in Robustly Optimized CBCT-Guided Pencil Beam Scanning Proton Beam Therapy: Lessons From a Real-World Cohort.Advances in radiation oncology · 2026Article
- An efficient automated approach for accumulated dose estimation in prostate cancer radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Interfractional shifts of the carina and hilum during radiotherapy for non-small cell lung cancer: A retrospective study to identify associated factors.Journal of applied clinical medical physics · 2025Article
- Key technologies and challenges in online adaptive radiotherapy for lung cancer.Chinese medical journal · 2025Review
- Assessing Dosimetric Benefits of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Treatment Frequencies for Lung Cancer.Advances in radiation oncology · 2025Article
- Are offline ART decisions for NSCLC impacted by the type of dose calculation algorithm?Technical innovations & patient support in radiation oncology · 2024Article
- Dosimetric benefits of adaptive radiation therapy for patients with stage III non-small cell lung cancer.Radiation oncology (London, England) · 2023Article
- Oesophageal IGRT considerations for SBRT of LA-NSCLC: barium-enhanced CBCT and interfraction motion.Radiation oncology (London, England) · 2021Article
- New developments in locally advanced nonsmall cell lung cancer.European respiratory review : an official journal of the European Respiratory Society · 2021Article
- Adaptive Radiation Therapy in the Treatment of Lung Cancer: An Overview of the Current State of the Field.Frontiers in oncology · 2021Review
- Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood.Frontiers in medicine · 2021Article
- Current status and future directions in unresectable stage III non-small cell lung cancer.Journal of clinical and translational research · 2020Review
- Adaptive radiation therapy of breast cancer by repeated imaging during irradiation.World journal of radiology · 2020Review
- Unanticipated Radiation Replanning for Stage III Non-small Cell Lung Cancer.Advances in radiation oncologyArticle
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10 authors.
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Abstract
objectivesAnatomic changes may occur during chemoradiation treatment for lung cancers, requiring adaptive replanning. Here we characterize these cases.
methodsWe retrospectively studied lung cancer cases that underwent resimulation and adaptive replanning during 1/2016-3/2019. We compared first and second CT-simulation regarding tumor location, timing of change, tumor volume, anatomical alteration and change in simulation technique. We also compared dosimetric parameters between the plans, recorded local control, and overall survival outcomes.
resultsOut of 281 patients, 58 underwent replanning (20.6%). Histology included small cell (22.4%) and non-small cell (77.6%). Stage III was in 91.4%. Mean radiation dose of 59.4 Gray (Gy) (range 50-66Gy).Tumor location was peribronchial in 53.5%. Timing of replanning was in the first, second and final third of the treatment course in 26%, 43% and 31% respectively. Changes in gross tumor volume were observed in 74%; mean gross tumor volume was 276.7cc
conclusionAdaptive replanning of radiation was performed in a fifth of locally advanced lung cancer patients. In most cases tumor volume decreased, or atelectasis resolved, causing mediastinal shifts, which, if unidentified and left uncorrected, may have led to local failure and increased toxicity. The heart V40Gy was reduced significantly in all cases, but significant reduction in lung doses was evident only if simulation technique was altered. ADVANCES IN KNOWLEDGE: In locally advanced lung cancer image-guidance with cone beam CT can detect significant mediastinal shifts and gross tumor volume changes that raise the need for adaptive replanning. Image guidance-triggered adaptive replanning should be added to the armament of advanced radiation treatment planning in locally advanced lung cancer.
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