Evidence map›Paper›PMID 31670258›Full record

ArticleJournal of the mechanical behavior of biomedical materials2020

On the characterization of interstitial fluid flow in the skeletal muscle endomysium.

Qiuyun Wang, Shaopeng Pei, X Lucas Lu, Liyun Wang, Qianhong Wu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Next Stage Approach to Tissue Engineering Skeletal Muscle.Bioengineering (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qiuyun WangCellular Biomechanics and Sports Science Laboratory, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA; Department of Mechanical Engineering, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA.
Shaopeng PeiDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
X Lucas LuDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
Liyun WangDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA. Electronic address: lywang@udel.edu.
Qianhong WuCellular Biomechanics and Sports Science Laboratory, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA; Department of Mechanical Engineering, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA. Electronic address: qianhong.wu@villanova.edu.
University of Delaware · USVillanova University · US

Funding

Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
Supplement to R01 Titled: Mechanosensing in the Bone Lacunar-Canalicular SystemR01AR054385 · NIAMS · UNIVERSITY OF DELAWARE · PI FARACH-CARSON, MARY C, WANG, LIYUN · 2007 to 2019
$3.8M
NIAMS NIH HHS R01 AR054385NIGMS NIH HHS P30 GM103333
6 · The paper itself

Abstract

In this paper, the interstitial fluid flow in skeletal muscle endomysium was examined using an in-situ indentation testing in combination with theoretical modelling. The objective was to understand the transport properties of the three-dimensional and highly hierarchical muscular interstitial matrices, which play important roles in muscle-bone cross-talk and signaling during musculoskeletal development and maintenance. Gastrocnemius muscles from four 3-month old calves were harvested and subjected to a creeping test using a custom-designed device. The experiments, in combination with an anatomy-based theoretical model, were used to capture the spatial-temporal response of the skeletal muscle to external impacts. For the first time, the detailed load-induced interstitial fluid pressurization in the muscle endomyseal space was obtained. The relative contribution from the solid muscle fibers and the interstitial fluid to the temporal loading response was captured. The paper presented herein provides important information regarding the mechanical environment within the muscle tissue, which could help the future study of muscle's response to forces and its subsequent signaling to surrounding tissues in vivo.

Indexed as

Extracellular FluidMuscle Fibers, SkeletalAnimalsBone and BonesCattleMuscle, SkeletalPhysical PhenomenaEffective permeabilityIndentationInterstitial transportMuscle-bone cross-talkMuscle endomysium

Identifiers

PMID31670258
PMCPMC7167341
OpenAlexW2980426465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.