Evidence map›Paper›PMID 31670188›Full record

ArticleVirology2020

Virus-induced natural killer cell lysis of T cell subsets.

Keith A Daniels, Carey L O'Donnell, Catherine Castonguay, Tara M Strutt, K Kai McKinstry, Susan L Swain, Raymond M Welsh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Persistent CD19Frontiers in cellular and infection microbiology · 2024
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Keith A DanielsDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Carey L O'DonnellDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Catherine CastonguayDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Tara M StruttImmunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA; NanoScience Technology Center, University of Central Florida, Orlando, FL, 32826, USA.
K Kai McKinstryImmunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA; NanoScience Technology Center, University of Central Florida, Orlando, FL, 32826, USA.
Susan L SwainDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Raymond M WelshDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA. Electronic address: raymond.welsh@umassmed.edu.
University of Massachusetts Chan Medical School · USUniversity of Central Florida · US

Funding

T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 2014 to 2018
$11.9M
Defining a memory checkpoint for CD4 T cellsR01AI118820 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SWAIN, SUSAN L · 2015 to 2019
$2.1M
NIAID NIH HHS R01 AI118820NIAID NIH HHS U19 AI109858
6 · The paper itself

Abstract

In addition to direct anti-viral activity, NK cells regulate viral pathogenesis by virtue of their cytolytic attack on activated CD4 and CD8 T cells. To gain insight into which differentiated T cell subsets are preferred NK targets, transgenic T cells were differentiated in vitro into Th0, Th1, Th2, Th17, Treg, Tc1, and Tc2 effector cells and then tested for lysis by enriched populations of lymphocytic choriomeningitis virus (LCMV)-induced activated NK cells. There was a distinct hierarchy of cytotoxicity in vitro and in vivo, with Treg, Th17, and Th2 cells being more sensitive and Th0 and Th1 cells more resistant. Some distinctions between in vitro vs in vivo generated T cells were explainable by type 1 interferon induction of class 1 histocompatibility antigens on the effector T cell subsets. NK receptor (NKR)-deficient mice and anti-NKR antibody studies identified no one essential NKR for killing, though there could be redundancies.

Indexed as

Cytotoxicity, ImmunologicAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesInterferonsKiller Cells, NaturalLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Natural Killer CellT-Lymphocyte SubsetsInterferonsReceptors, Natural Killer CellCD4CD8CytotoxicityInterferonLymphocyteLymphocytic choriomeningitis virusMouseNatural killerPathogenesisT cell

Identifiers

PMID31670188
PMCPMC7553765
OpenAlexW2980765838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.