Evidence map›Paper›PMID 31670139›Full record

ArticleMedical image analysis2020

Mitigating gyral bias in cortical tractography via asymmetric fiber orientation distributions.

Ye Wu, Yoonmi Hong, Yuanjing Feng, Dinggang Shen, Pew-Thian Yap

Abstract read
In one paragraph

Article in Medical image analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  4. A Large-scale Neural Model Inversion Framework for Effective Connectivity Estimation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ye WuDepartment of Radiology and Biomedical Research Imaging Center (BRIC) University of North Carolina at Chapel Hill, NC, U.S.A. Electronic address: wuye4567@email.unc.edu.
Yoonmi HongDepartment of Radiology and Biomedical Research Imaging Center (BRIC) University of North Carolina at Chapel Hill, NC, U.S.A.
Yuanjing FengInstitute of Information Processing and Automation, Zhejiang University of Technology, Hangzhou, China. Electronic address: fyjing@zjut.edu.cn.
Dinggang ShenDepartment of Radiology and Biomedical Research Imaging Center (BRIC) University of North Carolina at Chapel Hill, NC, U.S.A; Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea. Electronic address: dgshen@med.unc.edu.
Pew-Thian YapDepartment of Radiology and Biomedical Research Imaging Center (BRIC) University of North Carolina at Chapel Hill, NC, U.S.A. Electronic address: ptyap@med.unc.edu.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Development of Robust Brain Measurement Tools Informed by Ultrahigh Field 7T MRIR01EB006733 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2008 to 2020
$4.5M
Diagnosis of Alzheimer's Disease Using Dynamic High-Order Brain NetworksR01EB022880 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
Robust White Matter Morphometry with Small DatabasesR01NS093842 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
NIBIB NIH HHS R01 EB006733NIBIB NIH HHS R01 EB022880NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS093842
6 · The paper itself

Abstract

Diffusion tractography in brain connectomics often involves tracing axonal trajectories across gray-white matter boundaries in gyral blades of complex cortical convolutions. To date, gyral bias is observed in most tractography algorithms with streamlines predominantly terminating at gyral crowns instead of sulcal banks. This work demonstrates that asymmetric fiber orientation distribution functions (AFODFs), computed via a multi-tissue global estimation framework, can mitigate the effects of gyral bias, enabling fiber streamlines at gyral blades to make sharper turns into the cortical gray matter. We use ex-vivo data of an adult rhesus macaque and in-vivo data from the Human Connectome Project (HCP) to show that the fiber streamlines given by AFODFs bend more naturally into the cortex than the conventional symmetric FODFs in typical gyral blades. We demonstrate that AFODF tractography improves cortico-cortical connectivity and provides highly consistent outcomes between two different field strengths (3T and 7T).

Indexed as

AlgorithmsAnimalsCerebral CortexConnectomeDiffusion Tensor ImagingHumansImage Processing, Computer-AssistedMacaca mulattaWhite MatterAsymmetric fiber orientation distributionDiffusion MRIGyral biasTractography

Identifiers

PMID31670139
PMCPMC6935166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.