ArticlePlacenta2019
Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density.
Article in Placenta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- X-ray µ-CT contrast agents employing highly-concentrated low-viscosity layered double hydroxide nanoparticles for high-resolution imaging of vasculature.Materials advances · 2026Article
- Anatomical and Functional Insights Into Hyrtl's Anastomosis: Implications for Placental and Fetal Vascular Dynamics.Clinical anatomy (New York, N.Y.) · 2026Review
- Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development.bioRxiv : the preprint server for biology · 2026Article
- Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.Placenta · 2026Article
- sFlt-1/PlGF and beyond: angiolymphatic-associated signatures and emerging biomarkers in placental pathology.Vascular biology (Bristol, England) · 2025Review
- 3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography.PNAS nexus · 2025Article
- Cross-modal contrastive learning for unified placenta analysis using photographs.Patterns (New York, N.Y.) · 2024Article
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Impact of Fluoride Exposure on Rat Placenta: Foetal/Placental Morphometric Alterations and Decreased Placental Vascular Density.Biological trace element research · 2024Article
- Developments in functional imaging of the placenta.The British journal of radiology · 2023Review
- Article
- Microfocus computed tomography for fetal postmortem imaging: an overview.Pediatric radiology · 2023Article
- Three-dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography.Bioengineering & translational medicine · 2023Article
- Magnetic Resonance Imaging Angiography of Physiological and Pathological Pregnancy Placentas Ex Vivo: Protocol for a Prospective Pilot Study.JMIR research protocols · 2022Article
- Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- Placental contribution to neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021Review
- A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta.Journal of the Royal Society, Interface · 2021Article
- Structure-function relationships in the feto-placental circulation from in silico interpretation of micro-CT vascular structures.Journal of theoretical biology · 2021Article
- Article
- New Frontiers in Placenta Tissue Imaging.EMJ. Radiology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
introductionThere are considerable variations in villous morphology within a normal placenta. However, whether there is a reproducible spatial pattern of variation in villous vascular density is not known. Micro-CT provides three-dimensional volume imaging with spatial resolution down to the micrometre scale. In this study, we applied Micro-CT and histological analysis to investigate the degree of heterogeneity of vascularisation within the placenta.
methodTen term placentas were collected at elective caesarean section, perfused with contrast agent and imaged whole with Micro-CT. Eight full depth tissue blocks were then taken from each placenta and imaged. Sections were taken for histological analysis. Data was analysed to investigate vascular fill, and vascular density in relation to location from cord insertion to placental edge at each scale.
resultsWhole placental imaging revealed no spatially consistent difference in villous vessel density within the main placental tissue, although there was a great degree of heterogeneity. Both block imaging and histological analysis found a large degree of heterogeneity of vascular density within placentas, but no strong correlation between villous vascular density and block location (r DISCUSSION: This work presents a novel method for imaging the human placenta vascular tree using multiscale Micro-CT imaging. It demonstrates that there is a large degree of variation in vascular density throughout normal term human placentas. The three-dimensional data created by this technique could be used, with more advanced computer analysis, to further investigate the structure of the vascular tree.
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Registered trials
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