ArticleNeuroImage. Clinical2019
Gray matter abnormalities in language processing areas and their associations with verbal ability and positive symptoms in first-episode patients with schizophrenia spectrum psychosis.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Abnormal plasma oxidative stress markers in first-episode schizophrenia and associations with clinical symptoms and cognitive function.Schizophrenia (Heidelberg, Germany) · 2026Article
- Epidemiology of Communication Difficulty in Saudi Arabia: A Population-Based Analysis Using the National Disability Survey.Healthcare (Basel, Switzerland) · 2025Article
- Differences in the neural correlates of schizophrenia with positive and negative formal thought disorder in patients with schizophrenia in the ENIGMA dataset.Molecular psychiatry · 2024Article
- Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study.Research square · 2023Article
- Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia.Translational psychiatry · 2023Article
- Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder.Journal of clinical medicine · 2023Article
- Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping.Frontiers in psychiatry · 2020Article
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4 authors.
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Abstract
backgroundImpaired verbal communication is a prominent feature in patients with schizophrenia. Verbal communication difficulties adversely affect psychosocial outcomes and worsen schizophrenia's clinical manifestation. In the present study, we aimed to investigate associations among gray matter (GM) volumes in language processing areas (LPAs), verbal ability, and positive symptoms in first-episode patients (FEPs) with schizophrenia spectrum psychosis.
methodsWe enrolled 94 FEPs and 52 healthy controls (HCs) and subjected them to structural magnetic resonance imaging. The GM volumes of the bilateral pars opercularis (POp), pars triangularis (PTr), planum temporale (PT), Heschl's gyrus (HG), insula, and fusiform gyrus (FG), were estimated and compared between the FEPs and HCs. Verbal intelligence levels and positive symptom severity were examined for correlations with the left LPA volumes.
resultsThe GM volumes of the left POp, HG, and FG were significantly smaller in the FEPs than in the HCs, while the right regions showed no significant between-group difference. A multiple linear regression model revealed that larger left PT volume was associated with better verbal intelligence in FEPs. In exploratory correlation analysis, several LPAs showed significant correlations with the severity of positive symptoms in FEPs. The left FG volume had a strong inverse correlation with the severity of auditory verbal hallucinations, while the left PT volume was inversely associated with the severity of positive formal thought disorder and delusions. Moreover, the volume of the left insula was positively associated with the severity of bizarre behavior.
conclusionsThe present study suggests that GM abnormalities in the LPAs, which can be detected during the early stage of illness, may underlie impaired verbal communication and positive symptoms in patients with schizophrenia spectrum psychosis.
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