Evidence map›Paper›PMID 31669800›Full record

ArticleDrug and alcohol dependence2019

Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release.

Jonathan M Wai, Alexander Grassetti, Mark Slifstein, David Matuskey, Nabeel Nabulsi, Jim Ropchan, David Labaree, Yiyun Huang, Diana Martinez

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Acute depletion of dopamine precursors in the human brain: effects on functional connectivity and alcohol attentional bias.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jonathan M WaiDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 66, New York, NY 10038, USA. Electronic address: jonathan.wai@nyspi.columbia.edu.
Alexander GrassettiDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 66, New York, NY 10038, USA.
Mark SlifsteinDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 66, New York, NY 10038, USA.
David MatuskeyYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
Nabeel NabulsiYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
Jim RopchanYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
David LabareeYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
Yiyun HuangYale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA.
Diana MartinezDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Drive, Unit 66, New York, NY 10038, USA.
Columbia University · USYale Cancer Center · USYale University · USNew York State Psychiatric Institute

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Translational Clinical Research Fellowship on Substance Use DisordersT32DA007294 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Frances Rudnick Levin, Diana M Martinez · 1993 to 2026
$9.3M
Imaging the Neurochemistry of Binge-Drinking in College-Aged Young AdultsR01AA017648 · NIAAA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARTINEZ, DIANA M · 2010 to 2014
$1.6M
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA017648NIDA NIH HHS T32 DA007294
6 · The paper itself

Abstract

backgroundPrevious imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D

methodsThis study included 14 healthy controls (HC) and 14 young adult binge drinkers (BD), aged 18-25. The BD met National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria for binge drinking and the HC subjects were social drinkers. The subjects were scanned with [

resultsThere was no significant difference in the PET measures of D

conclusionIn this sample of 18-25-year-old binge drinkers without a diagnosis of a substance use disorder, there were no significant differences in D

Indexed as

AdolescentAdultBinge DrinkingCentral Nervous System StimulantsCorpus StriatumDopamineEthanolFemaleHumansMaleMethylphenidatePositron-Emission TomographyRacloprideRadioligand AssayReceptors, Dopamine D2Receptors, Dopamine D3Central Nervous System StimulantsDopamineEthanolMethylphenidateRacloprideReceptors, Dopamine D2Receptors, Dopamine D3AlcoholBinge drinkingDopamineImagingPETRaclopride

Identifiers

PMID31669800
PMCPMC6893096
OpenAlexW2980747985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.