Evidence map›Paper›PMID 31669484›Full record

ReviewExperimental neurology2020

Analyzing chemotherapy-induced peripheral neuropathy in vivo using non-mammalian animal models.

Anthony M Cirrincione, Sandra Rieger

Open access · greenAbstract readReview
In one paragraph

Review in Experimental neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Cellular Pathogenesis of Chemotherapy-Induced Peripheral Neuropathy: Insights FromFrontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anthony M CirrincioneDepartment of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, United States of America.
Sandra RiegerDepartment of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146, United States of America. Electronic address: srieger@miami.edu.
University of Miami · US

Funding

(PQ 9) Dysregulation of epidermal MMP-13 as cause of paclitaxel-induced peripheral neuropathyR01CA215973 · NCI · UNIVERSITY OF MIAMI CORAL GABLES · PI RIEGER, SANDRA · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA215973
6 · The paper itself

Abstract

Non-mammalian models of CIPN remain relatively sparse, but the knowledge gained from the few published studies suggest that these species have great potential to serve as a discovery platform for new pathways and underlying genetic mechanisms of CIPN. These models permit large-scale genetic and pharmacological screening, and they are highly suitable for in vivo imaging. CIPN phenotypes described in rodents have been confirmed in those models, and conversely, genetic players leading to axon de- and regeneration under conditions of chemotherapy treatment identified in these non-mammalian species have been validated in rodents. Given the need for non-traditional approaches with which to identify new CIPN mechanisms, these models bear a strong potential due to the conservation of basic mechanisms by which chemotherapeutic agents induce neurotoxicity.

Indexed as

Disease Models, AnimalAnimalsAntineoplastic AgentsCaenorhabditis elegansDrosophila melanogasterNeurotoxicity SyndromesPeripheral Nervous System DiseasesZebrafishAntineoplastic AgentsAxon degenerationChemotherapy-induced peripheral neuropathyCIPNDrosophilain vivo imagingNon-mammalianReviewZebrafish C. elegans

Identifiers

PMID31669484
PMCPMC6993950
OpenAlexW2982252353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.