ArticleNeuroscience2019
Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala.
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Assessing hearing and hearing loss in mice with OpenSABR (Open-source System for Auditory Brainstem Response)Journal of neurophysiology · 2026Article
- Brimonidine Therapy for Protection From Noise-Induced Hearing Loss.Aging cell · 2026Article
- Article
- Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Which Environmental Pollutants Are Toxic to Our Ears?-Evidence of the Ototoxicity of Common Substances.Toxics · 2024Review
- Cortical determinants of loudness perception and auditory hypersensitivity.bioRxiv : the preprint server for biology · 2024Article
- Investigation of the relationship between hyperacusis and auditory processing difficulties in individuals with normal hearing.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Tinnitus, sound intolerance, and mental health: the role of long-term occupational noise exposure.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Transient decrease in sound tolerance levels following hearing deprivation in normal-hearing subjects.Journal of otology · 2022Article
- A Review of the Neurobiological Mechanisms that Distinguish Between Loudness Recruitment and Hyperacusis.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function.Frontiers in neuroscience · 2022Article
- Hearing in Complex Environments: Auditory Gain Control, Attention, and Hearing Loss.Frontiers in neuroscience · 2022Review
- Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity.American journal of audiology · 2021Review
- Biased auditory nerve central synaptopathy is associated with age-related hearing loss.The Journal of physiology · 2021Article
- A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms.Neuroscience and biobehavioral reviews · 2021Review
- Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis.Current topics in behavioral neurosciences · 2021Article
- Occupational Noise: Auditory and Non-Auditory Consequences.International journal of environmental research and public health · 2020Review
- Tinnitus and hyperacusis: Central noise, gain and variance.Current opinion in physiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives rise to hyperacusis, a debilitating condition in which moderate intensity sounds are perceived abnormally loud. In an attempt to develop an animal model of loudness hyperacusis, we exposed rats to a 16-20 kHz noise at 104 dB SPL for 12 weeks. Behavioral reaction time-intensity functions were used to assess loudness growth functions before, during and 2-months post-exposure. During the exposure, loudness recruitment (R) was present in the region of hearing loss, but subtle evidence of hyperacusis (H) started to emerge at the border of the hearing loss. Unexpectedly, robust evidence of hyperacusis appeared below and near the edge of the hearing loss 2-months post-exposure. To identify the neural correlates of hyperacusis and test the central gain model of hyperacusis, we recorded population neural responses from the cochlea, auditory cortex and lateral amygdala 2-months post-exposure. Compared to controls, the neural output of the cochlea was greatly reduced in the noise group. Consistent with central gain models, the gross neural responses from the auditory cortex and amygdala were proportionately much larger than those from the cochlea. However, despite central amplification, the population responses in the auditory cortex and amygdala were still below the level needed to fully account for hyperacusis and/or recruitment. Having developed procedures that can consistently induce hyperacusis in rats, our results set the stage for future studies that seek to identify the neurobiological events that give rise to hyperacusis and to develop new therapies to treat this debilitating condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.