Evidence map›Paper›PMID 31669153›Full record

ArticleExperimental hematology2019

KRas

Cindy L Hochstetler, Yuxin Feng, Mehmet Sacma, Ashley K Davis, Mahil Rao, Chia-Yi Kuan, Li-Ru You, Hartmut Geiger, Yi Zheng

Open access · bronzeAbstract read
In one paragraph

Article in Experimental hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Effects of diet, BMP-2 treatment, and femoral skeletal injury on endothelial cells derived from the ipsilateral and contralateral limbs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Cindy L HochstetlerDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
Yuxin FengDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mehmet SacmaInstitute of Molecular Medicine and Stem Cell Aging, University of Ulm, Ulm, Germany.
Ashley K DavisDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Mahil RaoDivision of Pediatric Critical Care, Department of Pediatrics, Stanford University, Stanford, California.
Chia-Yi KuanDepartment of Neuroscience, University of Virginia, Charlottesville, Virginia.
Li-Ru YouInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan; Cancer Progression Research Center, National Yang-Ming University, Taipei, Taiwan.
Hartmut GeigerDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Institute of Molecular Medicine and Stem Cell Aging, University of Ulm, Ulm, Germany.
Yi ZhengDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio. Electronic address: yi.zheng@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversität Ulm · DENational Yang Ming Chiao Tung University · TWStanford University · USUniversity of Cincinnati · USUniversity of Virginia · US

Funding

ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
Leukemia stem cell polarity and differentiation therapyR01CA204895 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI MULLOY, JAMES C, ZHENG, YI · 2017 to 2021
$2.2M
Cdc42, hematopoietic stem cell polarity, and cell fateR01DK104814 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2016 to 2019
$2.0M
Blood stem cell aging and biomarker studiesR01HL134617 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI GEIGER, HARTMUT, ZHENG, YI · 2016 to 2019
$1.6M
Impact of an abnormal bone marrow endothelial niche on hematopoiesisF31HL136229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI HOCHSTETLER, CINDY · 2017 to 2019
$114k
NCI NIH HHS R01 CA204895NHLBI NIH HHS F31 HL136229NHLBI NIH HHS R01 HL134617NIDDK NIH HHS R01 DK104814NIEHS NIH HHS T32 ES007250
6 · The paper itself

Abstract

The bone marrow (BM) niche is an important milieu where hematopoietic stem and progenitor cells (HSPCs) are maintained. Previous studies have indicated that genetic mutations in various components of the niche can affect hematopoiesis and promote hematologic abnormalities, but the impact of abnormal BM endothelial cells (BMECs), a crucial niche component, on hematopoiesis remains incompletely understood. To dissect how genetic alterations in BMECs could affect hematopoiesis, we have employed a novel inducible Tie2-CreERT2 mouse model, with a tdTomato fluorescent reporter, to introduce an oncogenic KRas

Indexed as

Gene Expression Regulation, EnzymologicHematopoiesisMutation, MissenseSignal TransductionStem Cell NicheAmino Acid SubstitutionAnimalsFemaleHematopoietic Stem CellsInflammationMaleMiceMice, Mutant StrainsProto-Oncogene Proteins p21(ras)Hras protein, mouseProto-Oncogene Proteins p21(ras)

Identifiers

PMID31669153
PMCPMC6921092
OpenAlexW2981805027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.