ArticleThe Journal of allergy and clinical immunology2020
IgG Fc glycosylation as an axis of humoral immunity in childhood.
Abstract readLetter
In one paragraph
Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Elevated ozone activates maternal immunity to drive offspring IgG-mediated anaphylaxis through IgG glycosylation alterations.Nature communications · 2026Article
- Perioperative changes in IgG and plasma N-glycosylation in children with acute appendicitis and elective surgery: a prospective study.Croatian medical journal · 2026Article
- Assessment of IgG N-Glycan patterns in adult patients with immune thrombocytopenia and healthy individuals.Glycoconjugate journal · 2026Article
- Article
- Antibody glycosylation in neuroimmune diseases.Journal of translational medicine · 2025Review
- Serum N-glycosylation is altered in Nephropathic Cystinosis.Glycobiology · 2025Article
- SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults.Nature communications · 2025Article
- Immunoglobulin GFrontiers in immunology · 2025Article
- Immunoglobulin G glycosylation and its alterations in aging-related diseases.Acta biochimica et biophysica Sinica · 2024Review
- Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation.Vaccines · 2024Article
- The role ofFrontiers in immunology · 2023Review
- Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause.Frontiers in endocrinology · 2023Article
- Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations.Frontiers in immunology · 2023Review
- BNT162b2 induces robust cross-variant SARS-CoV-2 immunity in children.NPJ vaccines · 2022Article
- O-Glycoproteomic analysis of engineered heavily glycosylated fusion proteins using nanoHILIC-MS.Analytical and bioanalytical chemistry · 2022Article
- Harnessing IgG Fc glycosylation for clinical benefit.Current opinion in immunology · 2022Review
- Serologic Response toJournal of clinical microbiology · 2021Article
- Glycosylation and Aging.Advances in experimental medicine and biology · 2021Article
- Micro-Heterogeneity of Antibody Molecules.Experientia supplementum (2012) · 2021Review
- Estrogen-Driven Changes in Immunoglobulin G Fc Glycosylation.Experientia supplementum (2012) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Hao D ChengMolecular and Cellular Biology Program, Dartmouth College, Hanover, NH.
Irit TiroshDivision of Immunology, Boston Children's Hospital, Boston, Mass; Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Israel.
Noortje de HaanCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Henning StöckmannGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Barbara AdamczykGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Ciara A McManusGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Róisín O'FlahertyGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Gordon GrevilleGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Radka SaldovaGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland; College of Health and Agricultural Science, UCD School of Medicine, University College Dublin, Dublin, Ireland.
Francisco A BonillaDivision of Immunology, Boston Children's Hospital, Boston, Mass.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Gertjan J DriessenDepartment of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, The Hague, The Netherlands; Department of Pediatrics, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
Ingrid A HolmDivision of Endocrinology, Boston Children's Hospital, Boston, Mass.
Pauline M RuddGlycoscience Group, National Institute for Bioprocessing Research and Training, Dublin, Ireland.
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Margaret E AckermanMolecular and Cellular Biology Program, Dartmouth College, Hanover, NH; Thayer School of Engineering, Dartmouth College, Hanover, NH. Electronic address: Margaret.e.ackerman@dartmouth.edu.
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Boston, Mass; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Mass. Electronic address: pnigrovic@bwh.harvard.edu.
Funding
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7MPhysical Resources CoreP01AI120756 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2016 to 2020
$17.1MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MLy6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0MBridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2MDirecting Antibody Effector Activity via Controlled IgG Subclass SwitchingR01AI131975 · NIAID · DARTMOUTH COLLEGE · PI ACKERMAN, MARGARET E · 2017 to 2020
$2.6MT resident memory cells in arthritisR01AR075906 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2019 to 2023
$2.1MIgG glycosylation abnormalities in pediatric immunodeficiencyR21AI099435 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2012 to 2013
$491kNIAID NIH HHS P01 AI120756NIAID NIH HHS R01 AI131975NIAID NIH HHS R21 AI099435NIAMS NIH HHS P30 AR070253NIAMS NIH HHS R01 AR065538NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01 AR075906NIGMS NIH HHS P20 GM104416
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdolescentChildChild, PreschoolFemaleGlycoproteinsGlycosylationHumansImmunity, HumoralImmunoglobulin Fc FragmentsImmunoglobulin GInfantMaleGlycoproteinsglycosylated IgGImmunoglobulin Fc FragmentsImmunoglobulin G
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.