Evidence map›Paper›PMID 31668963›Full record

ArticleJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study.

Camden P Bay, Steven M Levy, Kathleen F Janz, Brian J Smith, John R Shaffer, Mary L Marazita, Trudy L Burns

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Camden P BayCenter for Clinical Investigation, Brigham & Women's Hospital, Boston, MA, USA. Electronic address: cpbay@bwh.harvard.edu.
Steven M LevyDepartment of Preventive and Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA, USA; Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
Kathleen F JanzDepartment of Health and Human Physiology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA, USA.
Brian J SmithHolden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Biostatistics, University of Iowa College of Public Health, Iowa City, IA, USA.
John R ShafferDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Clinical and Translational Science, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Trudy L BurnsDepartment of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA.
University of Iowa · USUniversity of Pittsburgh · USBrigham and Women's Hospital · USUniversity of Iowa Hospitals and Clinics · US

Funding

UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
XANTHINE OXIDASE PRODUCTS IN MODULATION OF ENDOTHELIAL DYSFUNCTIONM01RR000059 · NCRR · UNIVERSITY OF IOWA · PI ASHARE, ALIX · 1985 to 2007
$22.3M
Fluoride & Other Factors in Childhood and Adolescent Bone DevelopmentR01DE012101 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1998 to 2013
$11.9M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
Fluoride, Dietary, and Other Factors Related to Young Adult Bone Measures and Dental CariesR56DE012101 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 2015 to 2017
$3.5M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
Fluoride, Dietary, and Other Factors Related to Young Adult Bone Measures and Dental CariesU01DE028522 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 2019 to 2020
$658k
NCRR NIH HHS M01 RR000059NCRR NIH HHS UL1 RR024979NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01 DE012101NIDCR NIH HHS R56 DE012101NIDCR NIH HHS U01 DE018903NIDCR NIH HHS U01 DE028522
6 · The paper itself

Abstract

The foundation for osteoporosis risk is, in part, established during childhood, adolescence, and young adulthood, all periods of development when bone mass is acquired rapidly. The relative quantity of bone mass accrued is influenced by both lifestyle and genetic factors, although the genetic component is not yet well understood. The purpose of this study was to use a genome-wide association (GWA) analysis to discover single nucleotide polymorphisms (SNPs) associated with: (1) the sex-specific hip bone mineral content at approximately the age of 19 when the amount of bone accrued is near its peak; and (2) the sex-specific rate of hip bone mineral content accrual during the adolescent growth spurt. The Iowa Bone Development Study, a longitudinal cohort study exploring bone health in children, adolescents, and young adults was the source of data. From this cohort, n = 364 (190 females, 174 males) participants were included in GWA analyses to address (1) and n = 258 participants (125 females and 133 males) were included in GWA analyses to address (2). Twenty SNPS were detected having p < 1.0 × 10

Indexed as

Bone DensityGenome-Wide Association StudyAdolescentAdultBone and BonesBone DevelopmentChildFemaleHumansLongitudinal StudiesMaleYoung AdultAdolescent bone developmentbone massDKK2genome-wide association studylongitudinal

Identifiers

PMID31668963
PMCPMC7098844
OpenAlexW2891939339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.