Evidence map›Paper›PMID 31668904›Full record

ReviewTrends in endocrinology and metabolism: TEM2019

Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment.

Di Huang, Meng Deng, Shihuan Kuang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Di HuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN, USA; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA; Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
Meng DengDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA; Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA; School of Materials Engineering, Purdue University, West Lafayette, IN, USA; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. Electronic address: deng65@purdue.edu.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN, USA; Center for Cancer Research, Purdue University, West Lafayette, IN, USA. Electronic address: skuang@purdue.edu.

Funding

Notch signaling in liposarcomaR01CA212609 · NCI · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2017 to 2021
$1.8M
Polymeric nanoparticles for inductive browning of white adipose tissueR43DK115277 · NIDDK · ADIPO THERAPEUTICS, LLC · PI DENG, MENG · 2018 to 2018
$198k
NCI NIH HHS R01 CA212609NIDDK NIH HHS R43 DK115277
6 · The paper itself

Abstract

The global rise in the prevalence of obesity and affiliated metabolic syndrome poses a significant threat to human health. Various approaches, including bariatric surgery and pharmacotherapy, have been used in the clinical setting for obesity treatment; however, these conventional options remain ineffective and carry risks of adverse effects. Therefore, treatments with higher efficacy and specificity are urgently required. Emerging drug delivery systems use polymeric materials and chemical strategies to improve therapeutic efficacy and specificity through stabilization and spatiotemporally controlled release of antiobesity agents. In this review, we provide insights into current treatments for obesity with a focus on recent developments of polymeric carriers for enhanced antiobesity drug delivery.

Indexed as

Anti-Obesity AgentsDrug Delivery SystemsHumansObesityPolymersAnti-Obesity AgentsPolymersadiposeclinical translationdrug deliveryobesitypharmacotherapypolymeric carriers

Identifiers

PMID31668904
PMCPMC6927547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.