Evidence map›Paper›PMID 31668749›Full record

ArticleBiophysical journal2019

Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines.

Donya Ohadi, Danielle L Schmitt, Barbara Calabrese, Shelley Halpain, Jin Zhang, Padmini Rangamani

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Donya OhadiDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California.
Danielle L SchmittDepartment of Pharmacology, University of California San Diego, La Jolla, California.
Barbara CalabreseDivision of Biological Sciences and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California.
Shelley HalpainDivision of Biological Sciences and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, California.
Jin ZhangDepartment of Pharmacology, University of California San Diego, La Jolla, California.
Padmini RangamaniDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California. Electronic address: padmini.rangamani@eng.ucsd.edu.
University of California, San Diego · USSanford Consortium for Regenerative Medicine · US

Funding

Contemporary Approaches to Cancer Cell Signaling and CommunicationT32CA009523 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DONOGHUE, DANIEL J, YANG, JING · 1985 to 2025
$12.1M
NCI NIH HHS T32 CA009523
6 · The paper itself

Abstract

Dendritic spines are the primary excitatory postsynaptic sites that act as subcompartments of signaling. Ca

Indexed as

Computer SimulationSignal TransductionAdenylyl CyclasesAnimalsCalciumCalcium SignalingCalmodulinCyclic AMPCyclic AMP-Dependent Protein KinasesDendritic SpinesEnzyme ActivationFemaleKineticsMaleModels, BiologicalModels, Molecularadenylyl cyclase 1Adenylyl CyclasesCalciumCalmodulinCyclic AMPCyclic AMP-Dependent Protein KinasesPhosphoric Diester Hydrolases

Identifiers

PMID31668749
PMCPMC7031750
OpenAlexW2979293455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.