Observational studyJournal of cardiothoracic and vascular anesthesia2020
Preoperative Blood Pressure Complexity Indices as a Marker for Frailty in Patients Undergoing Cardiac Surgery.
Observational study in Journal of cardiothoracic and vascular anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Can laboratory test-based frailty indices contribute to frailty screening in emergency departments?Age and ageing · 2025Article
- Association between trajectories of systolic blood pressure and frailty outcome in middle-aged and older adults.The journal of nutrition, health & aging · 2024Article
- Blood pressure fragmentation as a new measure of blood pressure variability: association with predictors of cardiac surgery outcomes.Frontiers in physiology · 2024Article
- The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Mediated the Relationship Between Frailty and Arterial Stiffness in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort.Journal of clinical medicine · 2022Article
- Blood Pressure Complexity Discriminates Pathological Beat-to-Beat Variability as a Marker of Vascular Aging.Journal of the American Heart Association · 2022Article
- The Multiscale Dynamics of Beat-to-Beat Blood Pressure Fluctuation Links to Functions in Older Adults.Frontiers in cardiovascular medicine · 2022Article
- Article
- The Complexity of Blood Pressure Fluctuation Mediated the Effects of Hypertension on Walking Speed in Older Adults.Frontiers in aging neuroscience · 2021Article
- Associations between Neurocardiovascular Signal Entropy and Physical Frailty.Entropy (Basel, Switzerland) · 2020Article
- Impact of frailty in cardiac surgical patients-Assessment, burden, and recommendations.Annals of cardiac anaesthesiaReview
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveFrailty, a state of decreased physiological reserve, increases the risk of adverse outcomes. There is no standard tool for frailty during perioperative period. Autonomic dysfunction, an underlying process in frailty, could result in hemodynamic fluctuations. Complexity, the physiological adaptability of a system can quantify these fluctuations. The authors hypothesized that complexity could be a marker for frailty and explored their relationship in cardiac surgical patients.
designProspective, observational study.
settingSingle-center teaching hospital.
participantsThree hundred and sixty-four adult patients undergoing cardiac surgery.
interventionNone. MEASUREMENTS AND MAIN
resultsPreoperative beat-to-beat systolic arterial pressure (SAP) and mean arterial pressure (MAP) time series were obtained. Complexity indices were calculated using multiscale entropy (MSE) analysis. Frailty was assessed from: age >70 years, body mass index <18.5, hematocrit <35%, albumin <3.4 g/dL, and creatinine >2.0 mg/dL. The association between complexity indices and frailty was explored by logistic regression and predictive ability by C-statistics. In total, 190 (52%) patients had frailty. The complexity index (MSE
conclusionPreoperative BP complexity indices correlate and predict frailty. Impaired autonomic control is the underlying mechanism to explain this finding. A simple automated measure of preoperative BP complexity in the surgeon's office has the potential to reliably assess frailty.
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Registered trials
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