ArticleOphthalmology2020
Differential Effects of Aging in the Macular Retinal Layers, Neuroretinal Rim, and Peripapillary Retinal Nerve Fiber Layer.
Article in Ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Three-Year Changes in Visual Function in the Placebo Group of a Randomized Double-Blind International Multicenter Safety Study: Analysis of Electroretinography, Perimetry, Color Vision, and Visual Acuity in Individuals With Chronic Stable Angina Pectoris.Translational vision science & technology · 2022Trial
- Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Retinal and choroidal changes in diabetic patients before definitive diagnosis of diabetic retinopathy: a two-year prospective study.Journal of endocrinological investigation · 2026Article
- Proteomic clocks combined with deep learning phenotypes track eye aging and diseases.NPJ digital medicine · 2026Article
- Quantitative Analysis of Background Intraocular Pressure Volatility and Retinal Nerve Fiber Layer Loss in Cytomegalovirus Anterior Uveitis.Translational vision science & technology · 2026Article
- Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.Investigative ophthalmology & visual science · 2026Review
- Association of High-Density Lipoprotein Cholesterol with Macular Structure in Nonglaucomatous Individuals.Ophthalmology science · 2026Article
- A Structure-Function Dataset With Known Rates of Glaucomatous Progression.Translational vision science & technology · 2026Article
- Glaucoma Progression Detection Time Using OCT and OCTA in African and European Descendants.American journal of ophthalmology · 2026Article
- Retinal and Choriocapillaris Thickness and Age in Macaques in Development and Aging.Investigative ophthalmology & visual science · 2026Article
- Rapid Macular Thinning as a Biomarker for Geographical Atrophy.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Self images: an empirical enquiry into Rembrandt's self-portraits.Frontiers in psychiatry · 2026Article
- Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative ophthalmology & visual science · 2025Article
- Age-related decline in retinal function in marmosets.Scientific reports · 2025Article
- Retinal nerve fiber layer thickness profile in an Iranian adult population.Scientific reports · 2025Article
- Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes.Diabetologia · 2025Observational
- Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration.International journal of ophthalmology · 2025Article
- Optical coherence tomography findings in beta-thalassemia major: a systematic review and Meta-analysis.International journal of ophthalmology · 2025Article
- Sequence and Detectability of Changes in Macular Ganglion Cell Layer Thickness and Perfusion Density in Early Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
- Commented on by
- Commented on byReply.2020
Authors and funding
8 authors.
Funding
Abstract
purposeWe determined the differential aging effects of the inner 6 layers of the macula in contrast to the minimum neuroretinal rim width (MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness.
designCross-sectional, multicenter study.
participantsAn approximately equal number of white subjects with a normal ocular and visual field examination in each decade group from 20 to 90 years.
methodsOCT of the macula, optic nerve head, and peripapillary retina.
main outcome measuresSectoral measurements of the inner 6 layers of the macula; age-related decline of each of these layers; strength of the associations with age of the macular parameters, MRW, and peripapillary RNFL thickness; and association between ganglion cell layer (GCL) thickness and MRW and peripapillary RNFL thickness.
resultsThe study sample comprised 1 eye of 246 subjects with a median (range) age of 52.9 (19.8-87.3) years. Of the 6 layers, there was a statistically significant decline with age of only the GCL, inner plexiform layer, and inner nuclear layer thickness with rates of -0.11 μm/year, -0.07 μm/year, and -0.03 μm/year, respectively. These rates corresponded to 2.82%, 2.10%, and 0.78% loss per decade, respectively, and were generally uniform across sectors. The rate of loss of MRW and peripapillary RNFL thickness was -1.22 μm/year and -0.20 μm/year, corresponding to 3.75% and 2.03% loss per decade. However, the association of GCL thickness change with age (R
conclusionsIn concordance with histopathologic studies showing age-related loss of retinal ganglion cell axons, we showed a significant decline in GCL thickness, as well as MRW and peripapillary RNFL thickness. The stronger relationship between aging and GCL thickness compared with the rim or peripapillary RNFL may indicate that GCL thickness could be better suited to measure progression of structural glaucomatous loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.