Evidence map›Paper›PMID 31668493›Full record

ArticleSchizophrenia research2020

Association of a functional Claudin-5 variant with schizophrenia in female patients with the 22q11.2 deletion syndrome.

Yiran Guo, Larry N Singh, Yuankun Zhu, Raquel E Gur, Adam Resnick, Stewart A Anderson, Jorge I Alvarez

Abstract readLetter
In one paragraph

Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The role of tight junction proteins in the pathogenesis of schizophrenia.European archives of psychiatry and clinical neuroscience · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiran GuoCenter for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, United States.
Larry N SinghDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, United States.
Yuankun ZhuCenter for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, United States.
Raquel E GurDepartment of Psychiatry, The Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania, United States.
Adam ResnickCenter for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, United States.
Stewart A AndersonDepartment of Psychiatry, The Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania, United States.
Jorge I AlvarezDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, United States. Electronic address: alvaj@upenn.edu.

Funding

1/2-Brain-Behavior and Genetic Studies of the 22q11DSU01MH087626 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2010 to 2014
$6.5M
1/5 International Consortium on Brain and Behavior in 22q11.2 Deletion SyndromeU01MH101719 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2013 to 2016
$2.8M
IPSC phenotype, mitochondrial haplotype and psychosis in 22q11 deletion syndromeR01MH110185 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI ANDERSON, STEWART A · 2016 to 2018
$1.6M
The impact of hedgehog signaling during neuroinflammationK01NS097519 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ALVAREZ, JORGE IVAN · 2016 to 2018
$688k
NIMH NIH HHS R01 MH110185NIMH NIH HHS U01 MH087626NIMH NIH HHS U01 MH101719NINDS NIH HHS K01 NS097519
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultClaudin-5DiGeorge SyndromeFemaleHumansInflammationMaleSchizophreniaSex FactorsClaudin-5CLDN5 protein, human22q11.2DSBlood-brain barrierClaudin-5NeuroinflammationSchizophrenia

Identifiers

PMID31668493
PMCPMC7365141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.