Evidence map›Paper›PMID 31668479›Full record

Observational studyThe Journal of pediatrics2020

Birth Prevalence of Congenital Cytomegalovirus Infection in HIV-Exposed Uninfected Children in the Era of Combination Antiretroviral Therapy.

Murli U Purswani, Jonathan S Russell, Monika Dietrich, Kathleen Malee, Stephen A Spector, Paige L Williams, Toni Frederick, Sandra Burchett, Sean Redmond, Howard J Hoffman and 5 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01310023 (Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01310023 completednot on this map

Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2025Enrolled5,169ConditionsAntiretroviral Toxicity
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. [Congenital cytomegalovirus infection, is more prevalent in our country in newborns exposed to HIV?]Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Article
  4. Insight for Immunotherapy of HCMV Infection.International journal of biological sciences · 2021
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 1 country.

Murli U PurswaniDivision of Pediatric Infectious Disease, Department of Pediatrics, BronxCare Health System, Bronx; Icahn School of Medicine at Mount Sinai, NY. Electronic address: mpurswan@bronxleb.org.
Jonathan S RussellCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA.
Monika DietrichDepartment of Pediatrics, Tulane University School of Medicine, New Orleans, LA.
Kathleen MaleePsychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL.
Stephen A SpectorDepartment of Pediatrics, University of California San Diego, La Jolla, CA, and Rady Children's Hospital, San Diego, CA.
Paige L WilliamsCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA.
Toni FrederickMaternal, Child and Adolescent Program for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, CA.
Sandra BurchettDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA.
Sean RedmondDepartment of Communication Sciences and Disorders, University of Utah, Salt Lake City, UT.
Howard J HoffmanEpidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD.
Peter TorreSchool of Speech, Language and Hearing Sciences, San Diego State University, San Diego, CA.
Sonia LeeMaternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
Mabel L RiceChild Language Doctoral Program, University of Kansas, Lawrence, KS.
Tzy-Jyun YaoCenter for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, MA.
Pediatric HIV/AIDS Cohort Study
Harvard University · USCancer Research And Biostatistics · USIcahn School of Medicine at Mount Sinai · USNational Institute on Deafness and Other Communication Disorders · USNorthwestern University · USPediatric Infectious Diseases Society · USRady Children's Hospital-San Diego · USSan Diego State University · USTulane University · USUniversity of Kansas · USUniversity of Southern California · USUniversity of Utah · US

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itself

Abstract

objectivesTo estimate birth prevalence of congenital cytomegalovirus (cCMV) in HIV-exposed uninfected children born in the current era of combination antiretroviral therapy and describe cCMV-related neurodevelopmental and hearing outcomes. STUDY

designThe Surveillance Monitoring for ART Toxicities cohort study follows HIV-exposed uninfected children at 22 sites in the US and Puerto Rico. Birth cCMV prevalence was estimated in a subset of participants who had blood pellets collected within three weeks of birth and underwent ≥1 of 6 assessments evaluating cognitive and language development including an audiologic examination between 1 and 5 years of age. Detection of CMV DNA by polymerase chain reaction testing of peripheral blood mononuclear cells was used to diagnose cCMV. Proportions of suboptimal assessment scores were compared by cCMV status using Fisher exact test.

resultsMothers of 895 eligible HIV-exposed uninfected children delivered between 2007 and 2015. Most (90%) were on combination antiretroviral therapy, 88% had an HIV viral load of ≤400 copies/mL, and 93% had CD4 cell counts of ≥200 cells/μL. Eight infants were diagnosed with cCMV, yielding an estimated prevalence of 0.89% (95% CI, 0.39%-1.75%). After adjusting for a sensitivity of 70%-75% for the testing method, projected prevalence was 1.2%-1.3%. No differences were observed in cognitive, language and hearing assessments by cCMV status.

conclusionsAlthough birth cCMV prevalence in HIV-exposed uninfected children born to women with well-controlled HIV is trending down compared with earlier combination antiretroviral therapy-era estimates, it is above the 0.4% reported for the general US population. HIV-exposed uninfected children remain at increased risk for cCMV.

Indexed as

AdultAnti-Retroviral AgentsCase-Control StudiesChildChild, PreschoolCytomegalovirusCytomegalovirus InfectionsFemaleHIV InfectionsHIV SeronegativityHumansInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousPrevalencePuerto RicoAnti-Retroviral AgentscARTcCMVcongenitalcytomegalovirusHIV-exposed uninfectedprevalencewomen living with HIV

Identifiers

PMID31668479
PMCPMC6930703
OpenAlexW2981771112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.