Evidence map›Paper›PMID 31668132›Full record

ArticleVirulence2019

T-cell-specific mTOR deletion in mice ameliorated CD4

Hao Wang, Guangxu Bai, Na Cui, Wen Han, Yun Long

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  2. Cell death in sepsis: unveiling new perspectives on organ dysfunction.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Article
  5. USP9x promotes CD8Acta biochimica et biophysica Sinica · 2022
    Article
  6. mTOR pathway mediates endoplasmic reticulum stress-induced CD4Apoptosis : an international journal on programmed cell death · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Role of Autophagy in Lung Inflammation.Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hao WangDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.ORCID 0000-0001-7776-0882
Guangxu BaiDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.
Na CuiDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.
Wen HanDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.
Yun LongDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mammalian target of rapamycin (mTOR) pathway can mediate T-cell survival; however, the role of this pathway in T-cell survival during fungal sepsis is unclear. Here, we investigated the role of the mTOR pathway in CD4

Indexed as

ApoptosisAnimalsAutophagyCandidiasisCD4-Positive T-LymphocytesCell SurvivalGene DeletionMaleMiceMice, KnockoutSepsisSignal TransductionTOR Serine-Threonine KinasesTuberous SclerosismTOR protein, mouseTOR Serine-Threonine KinasesautophagyCD4+ T cellsLethal fungal sepsismammalian target of rapamycinsevere invasive candidiasis

Identifiers

PMID31668132
PMCPMC6844314
OpenAlexW2986423579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.