Evidence map›Paper›PMID 31668121›Full record

ArticleAutophagy2020

Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells.

Gerrit Müller, Charlotte Lübow, Günther Weindl

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gerrit MüllerInstitute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin , Berlin, Germany.
Charlotte LübowInstitute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin , Berlin, Germany.
Günther WeindlInstitute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin , Berlin, Germany.ORCID 0000-0002-4493-7597
University of Bonn · DEFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress and T ABBREVIATIONS: ATF: activating transcription factor; DC: dendritic cell; ChIP: chromatin immunoprecipitation; gDNA: genomic DNA; IL: interleukin; LAMP1: lysosomal associated membrane protein 1; LC: Langerhans cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MoDC: monocyte-derived DC; MoLC: monocyte-derived Langerhans-like cell; mtDNA: mitochondrial DNA; NAC: N-acetyl-L-cysteine; NLRP3: NLR family pyrin domain containing 3; PBMC: peripheral blood mononuclear cell; PI: propidium iodide; PYCARD/ASC: PYD and CARD domain containing; qRT-PCR: quantitative real-time PCR; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TLR: Toll-like receptor; TRAF6: TNF receptor associated factor 6; TNF: tumor necrosis factor; Ub: ubiquitin.

Indexed as

Adrenergic beta-AntagonistsAutophagyCell DifferentiationChloroquineDendritic CellsEndosomesGene Expression RegulationHumansInflammasomesInflammation MediatorsInterleukin-12Interleukin-23Langerhans CellsLysosomal-Associated Membrane Protein 1LysosomesMitochondriaAdrenergic beta-AntagonistsChloroquineInflammasomesInflammation MediatorsInterleukin-12Interleukin-23Lysosomal-Associated Membrane Protein 1Mitogen-Activated Protein Kinase 14NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPropranololReactive Oxygen SpeciesReceptors, Adrenergic, betaUbiquitinated ProteinsBeta blockersdendritic cellsIL1IL23AinflammationMAPK14/p38reactive oxygen speciesskin

Identifiers

PMID31668121
PMCPMC7469640
OpenAlexW2988862383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.