ArticleClinical and experimental otorhinolaryngology2020
Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography.
Article in Clinical and experimental otorhinolaryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.Research square · 2024Article
- Mammalian middle ear mechanics: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Predicting the Cochlear Dead Regions Using a Machine Learning-Based Approach with Oversampling Techniques.Medicina (Kaunas, Lithuania) · 2021Article
- Longitudinal optical coherence tomography to visualize the in vivo response of middle ear biofilms to antibiotic therapy.Scientific reports · 2021Article
- Optical coherence tomography's current clinical medical and dental applications: a review.F1000Research · 2021Review
- Mammalian Cochlear Hair Cell Imaging Using Optical Coherence Tomography (OCT): A Preliminary Study.The journal of international advanced otology · 2021Article
- Future Directions of Optical Coherence Tomography in Otology: A Morphological and Functional Approach.Clinical and experimental otorhinolaryngology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThis study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.
methodsFive rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.
resultsThe middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.
conclusionOCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.
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Registered trials
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