Evidence map›Paper›PMID 31667951›Full record

ArticleJournal of cellular and molecular medicine2020

Exosomes from human urine-derived stem cells enhanced neurogenesis via miR-26a/HDAC6 axis after ischaemic stroke.

Xiaozheng Ling, Guowei Zhang, Yuguo Xia, Qingwei Zhu, Juntao Zhang, Qing Li, Xin Niu, Guowen Hu, Yunlong Yang, Yang Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
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  4. Pleiotropic Effects of Exosomes as a Therapy for Stroke Recovery.International journal of molecular sciences · 2020
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiaozheng LingDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Guowei ZhangDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Yuguo XiaDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Qingwei ZhuDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Juntao ZhangInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Qing LiInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Xin NiuInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Guowen HuDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Yunlong YangInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Yang WangInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.
Zhifeng DengDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People' Hospital, Shanghai, China.ORCID 0000-0003-3529-0549
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous neurogenesis holds promise for brain repair and long-term functional recovery after ischaemic stroke. However, the effects of exosomes from human urine-derived stem cells (USC-Exos) in neurogenesis remain unclear. This study aimed to investigate whether USC-Exos enhanced neurogenesis and promoted functional recovery in brain ischaemia. By using an experimental stroke rat model, we found that intravenous injection of USC-Exos enhanced neurogenesis and alleviated neurological deficits in post-ischaemic stroke rats. We used neural stem cells (NSCs) subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) as an in vitro model of ischaemic stroke. The in vitro results suggested that USC-Exos promoted both proliferation and neuronal differentiation of NSCs after OGD/R. Notably, a further mechanism study revealed that the pro-neurogenesis effects of USC-Exos may be partially attributed to histone deacetylase 6 (HDAC6) inhibition via the transfer of exosomal microRNA-26a (miR-26a). Taken together, this study indicates that USC-Exos can be used as a novel promising strategy for brain ischaemia, which highlights the application of USC-Exos.

Indexed as

NeurogenesisAnimalsBrain IschemiaExosomesHistone Deacetylase 6HumansMaleMicroRNAsNeural Stem CellsRatsRats, Sprague-DawleyStrokeUrineHDAC6 protein, ratHistone Deacetylase 6MicroRNAsMIRN26 microRNA, ratexosomehistone deacetylase 6human urine-derived stem cellmicroRNA-26aneural stem cell

Identifiers

PMID31667951
PMCPMC6933407
OpenAlexW2985321231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.