ArticleJournal of general internal medicine2020
The Accuracy of Cardiovascular Pooled Cohort Risk Estimates in U.S. Older Adults.
Article in Journal of general internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- PEER simplified lipid guideline 2023 update: Prevention and management of cardiovascular disease in primary care.Canadian family physician Medecin de famille canadien · 2023Guideline
- Heart Stress and Blood Pressure Management in Older Adults: Post Hoc Analysis of the ASPREE Trial.Circulation · 2025Trial
- Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT.Journal of the American College of Cardiology · 2025Trial
- Metabolic signature across Life's Essential 8 profiles is heterogenous and may predict cardiovascular disease and mortality.Metabolism open · 2026Article
- External validation of the PREVENT risk score: performance and clinical utility in an Iranian population.Scientific reports · 2026Article
- Association between leukocyte-derived composite indices and premature coronary artery disease: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Digital intelligence for cardiometabolic health management in older adults: protocol for a community-based prospective cohort study.BMC geriatrics · 2025Article
- Social Determinants of Health Correlates and Atherosclerotic Cardiovascular Disease Risk Among Adults in Baltimore: The EngAGE With Heart Study.Journal of the American Heart Association · 2025Article
- Cardiovascular Risk Prediction in Older Adults.Current atherosclerosis reports · 2025Review
- Challenges in the prevention, treatment and management of cardiovascular disease among older adults.The Lancet regional health. Europe · 2025Review
- Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.Journal of the American Heart Association · 2025Article
- Performance of the American Heart Association PREVENT Cardiovascular Risk Equations in Older Adults.Circulation. Cardiovascular quality and outcomes · 2025Observational
- Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis.BMC primary care · 2025Article
- Age-Stratified Risk Categories for Cardiovascular Disease Prevention Therapies.JAMA cardiology · 2024Article
- Treating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events.Drugs & aging · 2024Review
- Phenotyping lipid profiles in type 2 diabetes: Risk association and outcomes from the Cardiovascular Health Study.American journal of preventive cardiology · 2024Article
- Article
- From Atherosclerotic Plaque to Myocardial Infarction-The Leading Cause of Coronary Artery Occlusion.International journal of molecular sciences · 2024Review
- Nontraditional Risk Markers for Incident Coronary Artery Calcium Among Persons ≥65 Years of Age.JACC. Advances · 2024Article
- Cardiovascular Disease Risk Scores and Incident Dementia and Cognitive Decline in Older Men and Women.Gerontology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe ACC/AHA guidelines for primary prevention rely on the Pooled Cohort Risk Equations (PCE) risk estimates of atherosclerotic cardiovascular disease (ASCVD) to guide treatment decisions. In light of the PCE being derived in younger populations, their accuracy in older adults is uncertain.
objectiveTo evaluate the predictive accuracy and calibration of the PCE in older individuals. DESIGN AND
settingWe estimated CVD predicted and observed risk among individuals from four large prospective cohort studies: Cardiovascular Health Study, Multiethnic Study of Atherosclerosis, Framingham Original, and Framingham Offspring.
participants12,527 overall individuals without ASCVD, including 9864 individuals aged 40-74 years and 2663 aged ≥75 years. MEASUREMENTS: We examined the operating characteristics of the PCE to estimate 5-year risk of stroke, MI, and CHD death overall and by age and sex strata. The associations between individual components of the PCE and cardiovascular events by age group (≥75 vs 40-74 years) were also evaluated.
resultsThe PCE had low discrimination for 5-year ASCVD risk in older (≥75 years) (c-statistic = 0.62, 95% CI 0.60-0.65) vs. younger (40-74 years) adults (c-statistic = 0.75, 95% CI 0.73-0.76). Calibration of the PCE was suboptimal in both older and younger adults, overestimating risk in the highest risk groups. Performance of the PCE in older adults was similarly poor when stratified by sex and age ≥ 80 years. LIMITATIONS: Since the PCE were derived from similar cohorts, though using different age groups and exams, this analysis likely overestimates the performance of the PCE.
conclusionThe performance of the PCE for ASCVD risk estimation in older adults is suboptimal; new models to effectively risk-stratify older adults are needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.