ArticleCancer causes & control : CCC2019
Changes in use of opioid therapy after colon cancer diagnosis: a population-based study.
Article in Cancer causes & control : CCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Observational
- Leveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data.Journal of biomedical informatics · 2024Article
- Improvement in patient-reported pain among patients with metastatic cancer and its association with opioid prescribing.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Patient and tumour characteristics of screening-age adults diagnosed with screen-detected versus symptomatic colon cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- An exploratory study of factors associated with long-term, high-dose opioid prescription in cancer patients in Japan based on a medical claims database.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Patterns and Trends in Receipt of Opioids Among Patients Receiving Treatment for Cancer in a Large Health System.Journal of the National Comprehensive Cancer Network : JNCCN · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo describe patterns of opioid use in cancer survivors.
methodsIn a cohort study of colon cancer patients diagnosed during 1995-2014 and enrolled at two Kaiser Permanente regions, we constructed quarterly measures of opioid use from 1 year before cancer diagnosis through 5 years after diagnosis to examine changes in use. Measures included any use, incident use, regular use (use ≥ 45 days in a 91-day quarter), and average daily dose (converted to morphine milligram equivalent, MME). We also assessed temporal trends of opioid use.
resultsOf 2,039 colon cancer patients, 11-15% received opioids in the four pre-diagnosis quarters, 68% in the first quarter after diagnosis, and 15-17% in each subsequent 19 quarters. Regular opioid use increased from 3 to 5% pre-diagnosis to 5-7% post diagnosis. Average dose increased from 15 to 17 MME/day pre-diagnosis to 14-22 MME/day post diagnosis (excluding the quarter in which cancer was diagnosed). Among post-diagnosis opioid users, 73-95% were on a low dose (< 20 MME/day). Over years, regular use of opioids increased in survivorship with no change in dosage.
conclusionOpioid use slightly increased following a colon cancer diagnosis, but high-dose use was rare. Research is needed to differentiate under- versus over-treatment of cancer pain.
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