ArticleCurrent genetics2020
R-SNARE FgSec22 is essential for growth, pathogenicity and DON production of Fusarium graminearum.
Article in Current genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Autophagic regulation of ferroportin 1 induces developmental ferroptosis in rice blast.Autophagy · 2025Article
- SNARE Protein CfSec22 Mediates Vesicular Trafficking to Regulate Growth, Conidiogenesis, and Pathogenesis ofMicroorganisms · 2025Article
- EvSec22, a SNARE Protein, Regulates Hyphal Growth, Stress Tolerance, and Nematicidal Pathogenicity inJournal of fungi (Basel, Switzerland) · 2025Article
- SNARE genes CcSec22 and CcSso1 coordinate fungal growth, sporulation, cell wall stress tolerance, endocytosis and full virulence in Cytospora chrysosperma.Scientific reports · 2025Article
- Genome-Wide Identification of SNARE Family Genes and Functional Characterization of an R-SNARE GeneJournal of fungi (Basel, Switzerland) · 2024Article
- Interplay of transport vesicles during plant-fungal pathogen interaction.Stress biology · 2023Review
- SNARE Protein Snc1 Is Essential for Vesicle Trafficking, Membrane Fusion and Protein Secretion in Fungi.Cells · 2023Review
- FgAP1Journal of fungi (Basel, Switzerland) · 2023Article
- SNARE Protein AoSec22 Orchestrates Mycelial Growth, Vacuole Assembly, Trap Formation, Stress Response, and Secondary Metabolism inJournal of fungi (Basel, Switzerland) · 2023Article
- Review
- The Endoplasmic Reticulum Cargo Receptor FgErv14 Regulates DON Production, Growth and Virulence inLife (Basel, Switzerland) · 2022Article
- Article
- The Golgin Protein RUD3 Regulates Fusarium graminearum Growth and Virulence.Applied and environmental microbiology · 2021Article
- The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis inFrontiers in microbiology · 2021Article
- Flippases play specific but distinct roles in the development, pathogenicity, and secondary metabolism of Fusarium graminearum.Molecular plant pathology · 2020Article
- FgEaf6 regulates virulence, asexual/sexual development and conidial septation in Fusarium graminearum.Current genetics · 2020Article
- The Dynamin-Like GTPase FgSey1 Plays a Critical Role in Fungal Development and Virulence in Fusarium graminearum.Applied and environmental microbiology · 2020Article
- Pathogenicity and Virulence Factors ofMicroorganisms · 2020Review
- FgPEX1 and FgPEX10 are required for the maintenance of Woronin bodies and full virulence of Fusarium graminearum.Current genetics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) facilitate intracellular vesicle trafficking and membrane fusion in eukaryotic cells, and play a vital role in growth, development and pathogenicity of phytopathogens. Fusarium head blight (FHB) caused by F. graminearum is one of the most devastating diseases of wheat and barley worldwide. Sec22 is a member of the SNARE family of proteins and its homologues have been shown to have diverse biological roles in different organisms. However, the functions of this protein in the development and pathogenesis of F. graminearum are currently unknown. In this study, we employed integrated biochemical, microbiological and molecular genetic approaches to investigate the roles of FgSec22 in F. graminearum. Our data reveal that this SNARE protein is localized to endoplasmic reticulum (ER) and is indispensable for normal conidiation, conidial morphology and pathogenesis of this phytopathogenic fungus. Our biochemical assay of deoxynivalenol (DON) reveals the active involvement of this protein in the production of this mycotoxin in F. graminearum. This has further been confirmed by qRT-PCR analyses of trichothecene (TRI) genes' expression where the ΔFgsec22 deletion mutant demonstrated a significant down-regulation of these genes in comparison to the wild-type PH-1. Unlike the wild-type and the complemented strain, the mutant strain presents a remarkable defect in colony formation which reflects the critical role it plays in vegetative growth. Collectively, our data support that the SNARE protein FgSec22 is required for vegetative growth, pathogenesis and DON biosynthesis in F. graminearum.
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