Evidence map›Paper›PMID 31667474›Full record

ArticleBrain communications2019

To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.

Ria de Haas, Lisa C M W Heltzel, Denise Tax, Petra van den Broek, Hilbert Steenbreker, Michel M M Verheij, Frans G M Russel, Adam L Orr, Ken Nakamura, Jan A M Smeitink

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  13. Brain sciences and the R words.Brain communications · 2023
    Article
  14. Mitochondrial-Dependent and Independent Functions of PINK1.Frontiers in cell and developmental biology · 2022
    Review
  15. Article
  16. How do we prevent scientific fraud?Brain communications · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ria de HaasDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Lisa C M W HeltzelDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Denise TaxCentral Animal Laboratory, Radboud University Medical Center, Nijmegen, The Netherlands.
Petra van den BroekDepartment of Pharmacology and Toxicology, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Hilbert SteenbrekerDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Michel M M VerheijDepartment of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Frans G M RusselDepartment of Pharmacology and Toxicology, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Adam L OrrHelen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Ken NakamuraGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Jan A M SmeitinkDepartment of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NLKhondrion (Netherlands) · NLUniversity of California, San Francisco · USWeill Cornell Medicine · US

Funding

Determining how neural activity impairs bioenergetics in PD pathogenesisR01NS091902 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI NAKAMURA, KEN · 2015 to 2019
$2.1M
NINDS NIH HHS R01 NS091902
6 · The paper itself

Abstract

The PTEN-induced putative kinase 1 knockout rat (Pink1

Indexed as

animal modeldopaminegenetic modelmicrodialysisParkinson’s disease

Identifiers

PMID31667474
PMCPMC6798789
OpenAlexW2972659590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.