Evidence map›Paper›PMID 31667442›Full record

ArticleBioactive materials2019

3D printing of silk fibroin-based hybrid scaffold treated with platelet rich plasma for bone tissue engineering.

Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Patrick Reid, Xiaohong Qin, Bin Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
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  6. Review
  7. 3D Bioprinting in Limb Salvage Surgery.Journal of functional biomaterials · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
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  15. Article
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  17. Article
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  19. Hydrogel-based microenvironment engineering of haematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liang WeiSchool of Textile Science and Engineering, Xi'an Polytechnic University, Xi'an, 710048, PR China.
Shaohua WuMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Mitchell KussMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Xiping JiangMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Runjun SunSchool of Textile Science and Engineering, Xi'an Polytechnic University, Xi'an, 710048, PR China.
Patrick ReidDepartment of Pathology & Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Xiaohong QinKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, PR China.
Bin DuanMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Funding

3D Bioprinting of Biomimetic Constructs for Rotator Cuff AugmentationR01AR073225 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, STREUBEL, PHILIPP N · 2018 to 2022
$1.6M
Modeling chikungunya virus infection in a vascularized bone modelR21AI140026 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DUAN, BIN, REID, PATRICK M · 2018 to 2019
$419k
NIAID NIH HHS R21 AI140026NIAMS NIH HHS R01 AR073225
6 · The paper itself

Abstract

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment of PRP did not significantly affect alkaline phosphatase (ALP) activity and expression, but significantly upregulated the gene expression levels of late osteogenic markers. This study demonstrated that the 3D printing of silk fibroin-based hybrid scaffolds, in combination with PRP post-treatment, might be a more efficient strategy to promote osteogenic differentiation of adult stem cells and has significant potential to be used for bone tissue engineering.

Indexed as

3D bioprintingCoatingGrowth factor cocktailHybrid scaffoldTissue engineering

Identifiers

PMID31667442
PMCPMC6812411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.