ArticleHeliyon2019
An immunofluorescence study on VEGF and extracellular matrix proteins in human periodontal ligament during tooth movement.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research.Journal of nanobiotechnology · 2026Review
- The effects of systemic and sustained hypoxia on orthodontic tooth movement in rats.Scientific reports · 2025Article
- Application of concentrated growth factor to autotransplantation with inflammation in recipient area.BMC oral health · 2021Article
- Articular Disc of a Human Temporomandibular Joint: Evaluation through Light Microscopy, Immunofluorescence and Scanning Electron Microscopy.Journal of functional morphology and kinesiology · 2021Article
- Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts.International journal of molecular sciences · 2020Article
- Histological and Immunofluorescence Study of Discal Ligaments in Human Temporomandibular Joint.Journal of functional morphology and kinesiology · 2020Article
- Immunofluorescence Evaluation of Myf5 and MyoD in Masseter Muscle of Unilateral Posterior Crossbite Patients.Journal of functional morphology and kinesiology · 2020Article
- Effects of sodium chloride on the gene expression profile of periodontal ligament fibroblasts during tensile strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2020Article
- Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study.Journal of functional morphology and kinesiology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The periodontal ligament (PDL) is a highly vascularized connective tissue surrounding the root of a tooth. In particular, the PDL is continuously exposed to mechanical stresses during the phases of mastication, and it provides physical, sensory, and trophic functions. It is known that the application of orthodontic force creates a change in periodontal structures. In fact, these forces generate a pressure on the ligament that closes the vessels. The aim of this study is to observe the modifications of vascular endothelial growth factor (VEGF) in the PDL and extracellular matrix proteins after application of a pre-calibrated and constant orthodontic force at different phases of treatment. We used a 50-g NiTi coiled spring and in vivo samples of PDL of maxillary and mandibular premolars of patients subjected to orthodontic treatment. These teeth were extracted at 1, 7, 14, 21, and 30 days, respectively, by application of force. The extraction of the PDL was effectuated by scarifying the radicular surface on the pressure and tension sides. The mechanical stress induced by the application of force caused an increase in the reactive type of metabolism of extracellular matrix proteins and modulation of neoangiogenesis until restoration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.