Evidence map›Paper›PMID 31667363›Full record

ArticleCommunications biology2019

Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3.

Ching-Feng Cheng, Hui-Chen Ku, Jing-Jy Cheng, Shi-Wei Chao, Hsiao-Fen Li, Pei-Fang Lai, Che-Chang Chang, Ming-Jaw Don, Hsi-Hsien Chen, Heng Lin

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  9. Eugenol inhibits preadipocyte differentiation and lipid accumulation via upregulating ATF3.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Ching-Feng Cheng *Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.
Hui-Chen Ku *Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan.ORCID 0000-0001-5169-1292
Jing-Jy Cheng *6Ph.D. Program in Clinical Drug Discovery from Botanical Herbs, Taipei Medical, University, Taipei, Taiwan.
Shi-Wei Chao4Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei, Taiwan.
Hsiao-Fen Li4Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei, Taiwan.
Pei-Fang Lai8Department of Emergency Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Che-Chang Chang4Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei, Taiwan.
Ming-Jaw Don7National Research Institute of Chinese Medicine, Taipei, Taiwan.
Hsi-Hsien Chen9Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Heng Lin4Ph.D. Program in Biotechnology Research and Development, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWNational Research Institute of Chinese Medicine · TWBuddhist Tzu Chi General Hospital · TWTaipei Medical University Hospital · TWTaipei Tzu Chi Hospital · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (

Indexed as

3T3-L1 CellsActivating Transcription Factor 3Adipocytes, BrownAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsAnti-Obesity AgentsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBody Temperature RegulationDiet, High-FatDisease Models, AnimalHumansInsulin ResistanceLipogenesisMaleMiceActivating Transcription Factor 3Anti-Obesity AgentsATF3 protein, humanAtf3 protein, mouseBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMlxipl protein, mouseOrlistatPlant ExtractsDiabetesDrug discoveryMedical researchObesityTranscription

Identifiers

PMID31667363
PMCPMC6813364
OpenAlexW2982223648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.