ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Structural Neuroimaging Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease: A Systematic Literature Review.Dementia and geriatric cognitive disorders · 2025Pooled it
- Thalamic Subregion Alterations and Short-Chain Fatty Acids in Schizophrenia and Ultra-High-Risk Individuals: A Cross-Sectional Study.Alpha psychiatry · 2026Article
- A Case Series on Longitudinal Hypothalamic Morphology in Mild Cognitive Impairment.Annals of geriatric medicine and research · 2026Article
- Thalamic nuclei insights into Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Spatial-temporal lipidomics reveals dysregulated lipid metabolism in mouse brain during Alzheimer's disease progression.Journal of advanced research · 2026Article
- Longitudinal subcortical volume changes and their correlations with multiple PET and fluid biomarkers in dominantly inherited Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Observational
- Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.Neuropsychology · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Cortical asymmetry in autosomal dominant Alzheimer's disease progression.Brain communications · 2026Article
- Atrophy patterns of deep gray matter nuclei in Alzheimer's disease and frontotemporal dementia.Journal of Alzheimer's disease : JAD · 2025Article
- The Cortical Asymmetry Index for subtyping dementia patients.European radiology · 2025Article
- Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer's Disease Versus Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Abnormal Gyrus Rectus Asymmetry in Alzheimer's Disease: An MRI-Based Parcellation Method.Brain sciences · 2025Article
- Thalamic microstructural alterations in cerebral small vessel disease with mild cognitive impairment: insights from diffusion kurtosis imaging.Neuroradiology · 2025Article
- Thalamic nuclei volumes are related to disease stage in patients with amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Article
- Association between retinal layer thickness and postoperative delirium in older patients.General psychiatry · 2025Article
- A reappraisal of the role of the mammillothalamic tract in memory deficits following stroke in the thalamus.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Gray Matter Asymmetry Alterations in Patients With Spinocerebellar Ataxia Type 3: A Voxel-Based Morphometric Comparison Study.CNS neuroscience & therapeutics · 2024Article
- Normative modeling of thalamic nuclear volumes.medRxiv : the preprint server for health sciences · 2024Article
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14 authors at 1 institution in 1 country.
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Abstract
introductionAlthough widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear.
methodsLateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amyloid-positive patients with mild cognitive impairment, and 18 patients with AD dementia). We compared lateralization indices across diagnostic groups and correlated them with clinical measures.
resultsAlthough overall asymmetry of the thalamus did not differ between groups, greater leftward lateralization of atrophy in the ventral nuclei was demonstrated in AD, compared with controls and amyloid-positive mild cognitive impairment. Increased posterior ventrolateral and ventromedial nuclei asymmetry were associated with worse cognitive dysfunction, informant-reported neuropsychiatric symptoms, and functional ability. DISCUSSION: Leftward ventral thalamic atrophy was associated with disease severity in AD. Our findings suggest the clinically relevant involvement of thalamic nuclei in the pathophysiology of AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.