Evidence map›Paper›PMID 31667327›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019

Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment.

Ana L M Almeida, Leopoldo A Pires, Evelyn A Figueiredo, Luciana V F Costa-Cunha, Leandro C Zacharias, Rony C Preti, Mário L R Monteiro, Leonardo P Cunha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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  11. Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ana L M AlmeidaDepartment of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
Leopoldo A PiresDepartment of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
Evelyn A FigueiredoDepartment of Ophthalmology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
Luciana V F Costa-CunhaJuiz de Fora Eye Hospital, Juiz de Fora, Minas Gerais, Brazil.
Leandro C ZachariasDivision of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.
Rony C PretiDivision of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.
Mário L R MonteiroDivision of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.
Leonardo P CunhaDepartment of Ophthalmology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.
Universidade de São Paulo · BRUniversidade Federal de Juiz de Fora · BRCentro de Ensino Superior de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment.

methodsPeripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire.

resultsMost inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters. DISCUSSION: The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population.

Indexed as

Alzheimer's diseaseDementiaGanglion cell layerMaculaMild cognitive impairmentOptical coherence tomographyOptic nerveRetinaRetinal nerve fiber layerSwept-source

Identifiers

PMID31667327
PMCPMC6811896
OpenAlexW2975432061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.