Evidence map›Paper›PMID 31667206›Full record

ArticleRegenerative therapy2019

Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions.

Yuichi Kojima, Atsunori Tsuchiya, Masahiro Ogawa, Shunsuke Nojiri, Suguru Takeuchi, Takayuki Watanabe, Kenji Nakajima, Yukio Hara, Junji Yamashita, Junichi Kikuta and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yuichi KojimaDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Atsunori TsuchiyaDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Masahiro OgawaDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Shunsuke NojiriDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Suguru TakeuchiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Takayuki WatanabeDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Kenji NakajimaResearch Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan.
Yukio HaraResearch Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan.
Junji YamashitaResearch Laboratory, Nihon Pharmaceutical Co Ltd, 34 Shin-izumi, Narita-City, Chiba, 286-0825, Japan.
Junichi KikutaDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Masaaki TakamuraDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Masaru IshiiDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Shuji TeraiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Niigata University Medical and Dental Hospital · JPNihon Pharmaceutical University · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) can be easily expanded. They can be acquired from medical waste such as adipose and umbilical cord tissues, are influenced by culturing conditions, and exert anti-inflammatory, antioxidant, anti-fibrotic, and angiogenic effects. We analyzed the multi-directional effects of MSCs cultured under hypoxic conditions and their underlying mechanisms in the treatment of liver cirrhosis in a mouse model.

methodsHuman bone marrow-derived MSCs cultured under hypoxic (5% O

resultsCAGE analysis revealed that the RNA expression levels of prostaglandin E synthase (

conclusionThe therapeutic effect of hypoMSCs was mediated by PGE2 and miR210 production and was greater than that of norMSCs. Therefore, MSCs can be manipulated to improve their therapeutic efficacy in the treatment of liver cirrhosis and could potentially serve in effective cell therapy. MSCs produce several factors with multidirectional effects and function as "conducting cells" in liver cirrhosis.

Indexed as

8-OHdG, DNA 8-hydroxy-2’-deoxyguanosineALB, AlbuminALP, Alkaline phosphataseALT, Alanine aminotransferaseCAGE, Cap analysis of gene expressionCCl4, Carbon tetrachlorideECM, Extracellular matrixHHSteC, Human Hepatic Stellate CellshypoMSCs, MSCs cultured under hypoxic oxygen (5% O2) conditionsHypoxic conditionid-BMM, Induced Bone Marrow Derived MacrophageLC, Liver cirrhosisLiver cirrhosisLPS, LipopolysaccharideMDA, MalondialdehydeMesenchymal stem cellsmiR210MSCs, Mesenchymal stem cellsNASH, Non-alcoholic steatohepatitisnorMSCs, MSCs cultured under normal oxygen (21% O2) conditionsPCR, Polymerase chain reactionPGE2PGE2, Prostaglandin E2SOD, Superoxide dismutaseT-Bil, Total bilirubin

Identifiers

PMID31667206
PMCPMC6813562
OpenAlexW2974844443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.