ArticleFrontiers in physics2018
Crowding Induces Entropically-Driven Changes to DNA Dynamics That Depend on Crowder Structure and Ionic Conditions.
Article in Frontiers in physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Protein crowders remodel RNA electrostatics, hydration, and dynamics: a challenge to steric crowding models.Nucleic acids research · 2026Article
- Abundant positively-charged proteins underlie JCVI-Syn3A's expanded nucleoid and ribosome distribution.PLoS computational biology · 2026Article
- Review
- Real-world modeling and simulation for the self-organized toroidal packing of a DNA chain.Scientific reports · 2025Article
- Article
- Molecular crowding suppresses mechanical stress-driven DNA strand separation.Biophysical journal · 2025Article
- Underestimated role of macromolecular crowding in bioengineeredMaterials today. Bio · 2025Article
- Melting Profile of DNA in Crowded Solution: Model-Based Study.International journal of molecular sciences · 2025Article
- Phage probes couple to DNA relaxation dynamics to reveal universal behavior across scales and regimes.Soft matter · 2025Article
- Insights on the effect of macromolecular crowding on transcription and its regulation.QRB discovery · 2025Article
- Article
- Macromolecular Crowding and DNA: Bridging the Gap between In Vitro and In Vivo.International journal of molecular sciences · 2023Review
- Crowding tunes the organization and mechanics of actin bundles formed by crosslinking proteins.FEBS letters · 2021Article
- Actin Bundle Nanomechanics and Organization Are Modulated by Macromolecular Crowding and Electrostatic Interactions.Frontiers in molecular biosciences · 2021Article
- Article
- Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking.Science advances · 2019Article
- Bridging the spatiotemporal scales of macromolecular transport in crowded biomimetic systems.Soft matter · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Macromolecular crowding plays a principal role in a wide range of biological processes including gene expression, chromosomal compaction, and viral infection. However, the impact that crowding has on the dynamics of nucleic acids remains a topic of debate. To address this problem, we use single-molecule fluorescence microscopy and custom particle-tracking algorithms to investigate the impact of varying macromolecular crowding conditions on the transport and conformational dynamics of large DNA molecules. Specifically, we measure the mean-squared center-of-mass displacements, as well as the conformational size, shape, and fluctuations, of individual 115 kbp DNA molecules diffusing through various
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