Evidence map›Paper›PMID 31667046›Full record

ArticleBeilstein journal of nanotechnology2019

Gold-coated plant virus as computed tomography imaging contrast agent.

Alaa A A Aljabali, Mazhar S Al Zoubi, Khalid M Al-Batanyeh, Ali Al-Radaideh, Mohammad A Obeid, Abeer Al Sharabi, Walhan Alshaer, Bayan AbuFares, Tasnim Al-Zanati, Murtaza M Tambuwala and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Beilstein journal of nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus.Chembiochem : a European journal of chemical biology · 2022
    Article
  5. Review
  6. Article
  7. Review
  8. Use of Nanoparticles in Delivery of Nucleic Acids for Melanoma Treatment.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Alaa A A AljabaliYarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan.ORCID https://orcid.org/0000-0002-9519-6338
Mazhar S Al ZoubiYarmouk University - Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan.ORCID https://orcid.org/0000-0003-0248-4777
Khalid M Al-BatanyehYarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan.
Ali Al-RadaidehHashemite University - Department of Medical Imaging, Zarqa, Jordan.
Mohammad A ObeidYarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan.ORCID https://orcid.org/0000-0001-9698-489X
Abeer Al SharabiNational Agricultural Research Center, Amman, Jordan.
Walhan AlshaerUniversity of Jordan - Cell Therapy Center, Amman, Jordan.ORCID https://orcid.org/0000-0003-2946-7328
Bayan AbuFaresYarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan.
Tasnim Al-ZanatiYarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan.ORCID https://orcid.org/0000-0002-4224-9555
Murtaza M TambuwalaSAAD Centre for Pharmacy and Diabetes, School of Pharmacy and Pharmaceutical Science Ulster University, Coleraine, UK.ORCID https://orcid.org/0000-0001-8499-9891
Naveed AkbarUniversity of Oxford - Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.
David J EvansJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID https://orcid.org/0000-0002-6290-2849
Yarmouk University · JOHashemite University · JOJohn Innes Centre · GBJohn Radcliffe Hospital · GBNational Energy Research Center · JOUniversity of Jordan · JOUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types.

Indexed as

biomedical imagingcomputed tomography (CT)goldnanotechnologytargetingviruses

Identifiers

PMID31667046
PMCPMC6808194
OpenAlexW2977670844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.