Evidence map›Paper›PMID 31666999›Full record

ArticleBone research2019

Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis.

Manli Tu, Mi Yang, Nanxi Yu, Gehua Zhen, Mei Wan, Wenlong Liu, Baochao Ji, Hairong Ma, Qiaoyue Guo, Peijian Tong and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  7. A Botanical Mixture (NWG11-02) ofJournal of microbiology and biotechnology · 2025
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  9. [Pathology of Cartilage-to-Bone Crosstalk: A New Angle for Animal Experimental Studies on Osteoarthritis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Manli Tu *1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Mi Yang *1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Nanxi Yu1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Gehua Zhen1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Mei Wan1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Wenlong Liu1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Baochao Ji4Department of Orthopedic Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054 Urumqi, Xinjiang Uygur Autonomous Region China.
Hairong Ma4Department of Orthopedic Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054 Urumqi, Xinjiang Uygur Autonomous Region China.
Qiaoyue Guo1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Peijian Tong5Department of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, 310006 Hangzhou, Zhejiang Province China.
Li Cao4Department of Orthopedic Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054 Urumqi, Xinjiang Uygur Autonomous Region China.
Xianghang Luo3Endocrinology Research Center of Xiangya Hospital, Central South University, 410008 Changsha, Hunan China.
Xu Cao1Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.
Johns Hopkins University · USJohns Hopkins Medicine · USXinjiang Medical University · CNCentral South University · CNFirst Affiliated Hospital of Xinjiang Medical University · CNZhejiang Chinese Medical University · CN

Funding

Trap+ Mononuclear Cells in Periosteal Bone FormationR01AR071432 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2017 to 2021
$2.2M
TGF-beta Activity in the Subchondral Bone and Onset of OAR01AR063943 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2013 to 2017
$2.2M
NIAMS NIH HHS R01 AR063943NIAMS NIH HHS R01 AR071432
6 · The paper itself

Abstract

Osteoarthritis (OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective disease-modifying therapy. Here, we report that elevated cyclooxygenase-2 (COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis (RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA (STR/Ort) mice and tumor necrosis factor-α transgenic RA mice. Thus, elevated COX-2 expression in subchondral bone induces both OA-associated and RA-associated joint cartilage degeneration. The inhibition of COX-2 expression can potentially modify joint destruction in patients with arthritis.

Indexed as

BonePathogenesis

Identifiers

PMID31666999
PMCPMC6804921
OpenAlexW2972428846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.