Evidence map›Paper›PMID 31666982›Full record

ReviewNPJ biofilms and microbiomes

Insights into flagellar function and mechanism from the squid-vibrio symbiosis.

Marie-Stephanie Aschtgen, Caitlin A Brennan, Kiel Nikolakakis, Stephanie Cohen, Margaret McFall-Ngai, Edward G Ruby

Open access · goldAbstract readReview
In one paragraph

Review in NPJ biofilms and microbiomes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Host-Associated Biofilms:Microorganisms · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Lighting the way: how theJournal of bacteriology · 2024
    Review
  8. Journal of bacteriology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. The Vibrio Polar Flagellum: Structure and Regulation.Advances in experimental medicine and biology · 2023
    Article
  13. Antibiofilm and Antiquorum Sensing Potential ofFoods (Basel, Switzerland) · 2022
    Article
  14. Review
  15. Nocturnal Acidification: A Coordinating Cue in theInternational journal of molecular sciences · 2022
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Marie-Stephanie Aschtgen1Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0003-2413-8226
Caitlin A Brennan1Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706 USA.ORCID 0000-0002-6074-9502
Kiel Nikolakakis1Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706 USA.
Stephanie CohenLaboratory for Biological Geochemistry, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne, and Center for Advanced Surface Analysis, Institute of Earth Sciences, Université de Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-8835-4836
Margaret McFall-Ngai3Kewalo Marine Laboratory, University of Hawaii-Manoa, Honolulu, HI 96813 USA.
Edward G Ruby3Kewalo Marine Laboratory, University of Hawaii-Manoa, Honolulu, HI 96813 USA.ORCID 0000-0002-4112-4830
University of Hawaiʻi at Mānoa · USUniversity of Wisconsin–Madison · USUniversity of Wisconsin–Green Bay · US

Funding

Vibrio fischeri as a Model for Bacterial ColonizationR37AI050661 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI MARGARET J MC FALL-NGAI, Edward G Ruby · 2018 to 2026
$5.4M
Vibrio Virulence Determinants in a Benign ColonizationR01OD011024 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2012 to 2020
$3.9M
Vibrio colonization determinants in symbiosisR01GM135254 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI MC FALL-NGAI, MARGARET J, RUBY, EDWARD G · 2020 to 2023
$1.9M
Resistance and resiliency in a natural host-microbe symbiosisR01GM099507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RUBY, EDWARD G · 2012 to 2015
$1.4M
NIAID NIH HHS R37 AI050661NIGMS NIH HHS R01 GM099507NIGMS NIH HHS R01 GM135254NIH HHS R01 OD011024
6 · The paper itself

Abstract

Flagella are essential and multifunctional nanomachines that not only move symbionts towards their tissue colonization site, but also play multiple roles in communicating with the host. Thus, untangling the activities of flagella in reaching, interacting, and signaling the host, as well as in biofilm formation and the establishment of a persistent colonization, is a complex problem. The squid-vibrio system offers a unique model to study the many ways that bacterial flagella can influence a beneficial association and, generally, other bacteria-host interactions.

Indexed as

Host Microbial InteractionsSymbiosisAliivibrio fischeriAnimalsBiofilmsDecapodiformesFlagellaCellular microbiologySymbiosis

Identifiers

PMID31666982
PMCPMC6814793
OpenAlexW2981935532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.