ArticleLight, science & applications2019
Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.
Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- All-fiber photoacoustic endomicroscopy reveals layer-specific angiogenesis-oxygenation uncoupling in experimental colitis.Science advances · 2026Article
- Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.Placenta · 2026Article
- From light to sound: Seeing and hearing the placenta in health and disease.Science advances · 2026Review
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- Nanomedicines for Improved Management of Ectopic Pregnancy: A Narrative Review.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Image reconstruction of multispectral sparse sampling photoacoustic tomography based on deep algorithm unrolling.Photoacoustics · 2024Article
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Fetal Oxygenation from the 23rd to the 36th Week of Gestation Evaluated through the Umbilical Cord Blood Gas Analysis.International journal of molecular sciences · 2023Article
- Fetal oxygenation in the last weeks of pregnancy evaluated through the umbilical cord blood gas analysis.Frontiers in pediatrics · 2023Article
- Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity.Nature reviews. Endocrinology · 2022Review
- A Mouse Model of Endometriosis with Nanoparticle Labeling for In Vivo Photoacoustic Imaging.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Three-Dimensional Deep-Tissue Functional and Molecular Imaging by Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT).IEEE transactions on medical imaging · 2022Article
- Adaptive dual-speed ultrasound and photoacoustic computed tomography.Photoacoustics · 2022Article
- Video-rate full-ring ultrasound and photoacoustic computed tomography with real-time sound speed optimization.Biomedical optics express · 2022Article
- Mouse embryo phenotyping with optical coherence tomography.Frontiers in cell and developmental biology · 2022Review
- Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring.Experimental neurology · 2022Review
- Nonlinear mechanisms in photoacoustics-Powerful tools in photoacoustic imaging.Photoacoustics · 2021Review
- Ultrasmall PEI-Decorated BiFrontiers in pharmacology · 2021Article
- Spherical-view photoacoustic tomography for monitoringPhotoacoustics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of placental function in embryonic development, it remains poorly understood and challenging to characterize, primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during pregnancy. We developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant mice. Functional changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine green. Structural phenotyping of the cross-sectional scans highlighted different internal organs, whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions, rendering a strong correlation with the amount of oxygen administered. Likewise, the placental function in protecting the embryo from extrinsically administered agents was substantiated. The proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.