ArticleOpen access Macedonian journal of medical sciences2019
Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants.
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06444334 (Evaluation of the Effect of Laser Biostimulation on Implant Covered With PRF in Controlled Diabetic Patients), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effect of Laser Biostimulation on Implant Covered With PRF in Controlled Diabetic Patients: A Randomized Clinical Trial
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effects of platelet concentrates on implant stability and marginal bone loss: a systematic review and meta-analysis.BMC oral health · 2021Pooled it
- Photobiomodulation in Dental Implant Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Dentistry journal · 2026Review
- Impact of autologous platelet concentrates on the osseointegration of dental implants.Periodontology 2000 · 2025Review
- Growth factors and osseointegration in dental implants - A review.Bioinformation · 2025Article
- Efficacy of Platelet-Rich Plasma and Platelet-Rich Fibrin in Enhancing Dental Implant Osseointegration.Galen medical journal · 2024Review
- Analysis of the effects of concentrated growth factor and low-level laser therapy on the bone healing.Heliyon · 2023Article
- Interaction between Different Implant Surfaces and Liquid Fibrinogen: A Pilot In Vitro Experiment.BioMed research international · 2021Article
- Clinical Efficacy of Photobiomodulation on Dental Implant Osseointegration: A Systematic Review.Saudi journal of medicine & medical sciencesReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe success of implants is associated first with their osseointegration, and later on with their survival rate. In recent years, many efforts have been exerted to develop implant design, geometry, materials and techniques to enhance the osseointegration process and also to increase the success rate of implant procedures. New techniques, like leukocyte and platelet-rich fibrin (L-PRF) and low-level laser treatment (LLLT), have been developed to enhance the osseointegration around dental implants.
aimThis study aims at accelerating bone osseointegration process around dental implant using new techniques to increase the success rate, to allow immediate or early loading of a dental implant, and to make a comparison between the various new techniques in dental implant procedures to figure out which technique will achieve the best results.
methodsThe study was conducted on a random sample of 40 male patients. Dental implants were placed in the posterior areas of the lower jaw. Patients were divided randomly into 4 groups; control group, LLLT group, L-PRF group and L-PRF plus LLLT group. They were assessed using cone-beam computed tomography (CBCT).
resultsThe results showed significant differences between all groups over different measured times. All the groups showed improvement in comparison with Normal group, where L-PRF group showed the best result followed by (L-PRF+LLLT) group, while the LLLT group showed the least improvement in comparison with bothL-PRF group and (L-PRF+LLLT) group.
conclusionThe study demonstrates that L-PRF gives a better performance in the osseointegration around dental implants than LLLT.
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Registered trials
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