ReviewInfectious diseases2019
Resurgence of Syphilis in the United States: An Assessment of Contributing Factors.
Review in Infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection.Health and quality of life outcomes · 2024Pooled it
- Management of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine.Journal of hospital medicine · 2022Pooled it
- Prevalence of syphilis among people living with HIV and its implication for enhanced coinfection monitoring and management in China: A meta-analysis.Frontiers in public health · 2022Pooled it
- Maternal Health Outcomes Associated With Syphilis Infection During Pregnancy: Evidence From a Large US All-Payer Hospital-Centered Administrative Database.Open forum infectious diseases · 2026Article
- Ocular Syphilis in the Era of Resurgence: Clinical Characteristics and Diagnostic Challenges in a Single-Center Cohort.Medicina (Kaunas, Lithuania) · 2026Article
- Syphilis-related mortality in the United States, 2021-2025: trends, demographic disparities, and clinical implications.BMC infectious diseases · 2026Article
- Review
- Characterising the rate of syphilis diagnosis among people incarcerated in state-level prisons: a cohort study in Washington state 2013-2023.Sexually transmitted infections · 2026Article
- Exosomal miR-1246 in Syphilis Serofast State: Diagnostic Value and NLRP3 Inflammasome Suppression.Immunity, inflammation and disease · 2026Article
- Article
- Prevalence of chlamydial, gonococcal and syphilis positivity by anatomical site and sex via self-collected biospecimens using at-home testing kits among a large and diverse cohort of men and women enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in the USA.Sexually transmitted infections · 2026Article
- Evaluating syphilis transmission among MSM population: a mathematical model for reinfection, two-stage treatment, and treatment failure.Frontiers in public health · 2026Article
- Epidemiological analysis of syphilis trends, disparities, and public health implications in the United States, 2018-2022.BMC infectious diseases · 2025Article
- Dismantling Stereotypes About Being Top, Versatile, or Bottom: Sexual Minority Men's Anal Sex Position Identity as It Relates to Attraction, Sexual Behavior, and Anthropomorphic Characteristics.Journal of sex research · 2025Article
- Intersecting Risk Factors Associated With High Syphilis Seroprevalence Among a Street-Involved Population in Canada.Open forum infectious diseases · 2025Article
- Syphilis and HIV co-infection presenting with a pituitary abscess: A rare case presentation.Radiology case reports · 2025Article
- Transmission dynamics of the 2022 mpox epidemic in New York City.Nature medicine · 2025Article
- Proposed approaches for public health surveillance: A literature review for the Canadian National HIV Surveillance Program.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025Article
- Analysis of 2019 Ohio Disease Intervention Specialist Records for Syphilis Cases Using Clustering Algorithms.Sexually transmitted diseases · 2025Article
- Unraveling the resurgence of syphilis: a deep dive into the epidemic sweeping across the United States; a mini review.Annals of medicine and surgery (2012) · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, there has been a marked resurgence of syphilis in the United States despite the availability of effective treatments and previously reliable prevention strategies. The majority of cases are among the population of men who have sex with men (MSM); however, there has also been a recent increase among premenopausal women, coinciding with a concerning rise of congenital cases. The resurgence of syphilis can be largely attributed to changing social and behavioral factors, especially among young MSM. The biological association of syphilis with human immunodeficiency virus (HIV) transmission and acquisition is particularly alarming because of the increased individual and healthcare burden. In addition, some individual actions and public health efforts that are meant to reduce the risk of acquiring HIV may actually lead to risk compensation that facilitates the transmission of syphilis. Untreated syphilis is associated with detrimental health outcomes; therefore, both effective prevention strategies and treatment of this systemic disease have important short-term and long-term public health implications. This article offers a review of social and behavioral factors contributing to the current resurgence and recommendations for reducing syphilis incidence through medical and public health prevention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.