Evidence map›Paper›PMID 31666704›Full record

ArticleNature2019

Hierarchical organization of cortical and thalamic connectivity.

Julie A Harris, Stefan Mihalas, Karla E Hirokawa, Jennifer D Whitesell, Hannah Choi, Amy Bernard, Phillip Bohn, Shiella Caldejon, Linzy Casal, Andrew Cho and 32 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 400 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 1 pooled it
37.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 1 synthesis or guideline pooled it, 820 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  8. Article
  9. Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 4 institutions in 2 countries.

Julie A Harris *Allen Institute for Brain Science, Seattle, WA, USA. julieha@alleninstitute.org.
Stefan Mihalas *Allen Institute for Brain Science, Seattle, WA, USA.
Karla E HirokawaAllen Institute for Brain Science, Seattle, WA, USA.
Jennifer D WhitesellAllen Institute for Brain Science, Seattle, WA, USA.
Hannah ChoiAllen Institute for Brain Science, Seattle, WA, USA.
Amy BernardAllen Institute for Brain Science, Seattle, WA, USA.
Phillip BohnAllen Institute for Brain Science, Seattle, WA, USA.
Shiella CaldejonAllen Institute for Brain Science, Seattle, WA, USA.
Linzy CasalAllen Institute for Brain Science, Seattle, WA, USA.
Andrew ChoAllen Institute for Brain Science, Seattle, WA, USA.
Aaron FeinerAllen Institute for Brain Science, Seattle, WA, USA.
David FengAllen Institute for Brain Science, Seattle, WA, USA.
Nathalie GaudreaultAllen Institute for Brain Science, Seattle, WA, USA.
Charles R GerfenLaboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD, USA.
Nile GraddisAllen Institute for Brain Science, Seattle, WA, USA.
Peter A GroblewskiAllen Institute for Brain Science, Seattle, WA, USA.
Alex M HenryAllen Institute for Brain Science, Seattle, WA, USA.
Anh HoAllen Institute for Brain Science, Seattle, WA, USA.
Robert HowardAllen Institute for Brain Science, Seattle, WA, USA.
Joseph E KnoxAllen Institute for Brain Science, Seattle, WA, USA.
Leonard KuanAllen Institute for Brain Science, Seattle, WA, USA.
Xiuli KuangWenzhou Medical University, Wenzhou, P. R. China.
Jerome LecoqAllen Institute for Brain Science, Seattle, WA, USA.
Phil LesnarAllen Institute for Brain Science, Seattle, WA, USA.
Yaoyao LiWenzhou Medical University, Wenzhou, P. R. China.
Jennifer LuvianoAllen Institute for Brain Science, Seattle, WA, USA.
Stephen McConougheyAllen Institute for Brain Science, Seattle, WA, USA.
Marty T MortrudAllen Institute for Brain Science, Seattle, WA, USA.
Maitham NaeemiAllen Institute for Brain Science, Seattle, WA, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Seung Wook OhAllen Institute for Brain Science, Seattle, WA, USA.
Benjamin OuelletteAllen Institute for Brain Science, Seattle, WA, USA.
Elise ShenAllen Institute for Brain Science, Seattle, WA, USA.
Staci A SorensenAllen Institute for Brain Science, Seattle, WA, USA.
Wayne WakemanAllen Institute for Brain Science, Seattle, WA, USA.
Quanxin WangAllen Institute for Brain Science, Seattle, WA, USA.
Yun WangAllen Institute for Brain Science, Seattle, WA, USA.
Ali WillifordAllen Institute for Brain Science, Seattle, WA, USA.
John W PhillipsAllen Institute for Brain Science, Seattle, WA, USA.
Allan R JonesAllen Institute for Brain Science, Seattle, WA, USA.
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.
Allen Institute for Brain Science · USAllen Institute · USWenzhou Medical University · CNNational Institute of Mental Health · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
High-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3M
Mouse Cell Type-Specific Brain Mapping in Health and DiseaseR01AG047589 · NIA · ALLEN INSTITUTE · PI HARRIS, JULIE · 2014 to 2018
$3.4M
NEI NIH HHS R01 EY023173NIA NIH HHS R01 AG047589NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable principles of organization remain mostly unknown. Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource

Indexed as

AnimalsAxonsCerebral CortexFemaleIntegrasesMaleMiceMice, Inbred C57BLNeural PathwaysThalamusCre recombinaseIntegrases

Identifiers

PMID31666704
PMCPMC8433044
OpenAlexW2982557070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.