Evidence map›Paper›PMID 31666702›Full record

ArticleNature2019

Immunity to commensal papillomaviruses protects against skin cancer.

John D Strickley, Jonathan L Messerschmidt, Mary E Awad, Tiancheng Li, Tatsuya Hasegawa, Dat Thinh Ha, Henry W Nabeta, Paul A Bevins, Kenneth H Ngo, Maryam M Asgari and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 143 citations in OpenAlex.

  1. Trial
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  13. Cutaneous T cell immunity.Nature immunology · 2025
    Review
  14. Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

John D Strickley *Center for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jonathan L Messerschmidt *Center for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Mary E AwadCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Tiancheng LiCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Tatsuya HasegawaCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dat Thinh HaCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Henry W NabetaJames Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Paul A BevinsCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kenneth H NgoCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maryam M AsgariDepartment of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Rosalynn M NazarianDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Victor A NeelDepartment of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Alfred Bennett JensonJames Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Joongho JohJames Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
Shadmehr DemehriCenter for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. sdemehri1@mgh.harvard.edu.
Harvard University · USCenter for Cancer Research · USJames Graham Brown Foundation · USMassachusetts General Hospital · USUniversity of Louisville · US

Funding

Epithelium-derived alarmins role in breast cancer immunopreventionU01CA233097 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DEMEHRI, SHADMEHR · 2018 to 2022
$4.0M
THE MECHANISM OF TSLP ANTI-TUMOR EFFECTS IN THE SKINDP5OD021353 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI DEMEHRI, SHADMEHR · 2015 to 2019
$2.2M
The Role of Allergic Contact Dermatitis in Skin CarcinogenesisK08AR068619 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DEMEHRI, SHADMEHR · 2015 to 2019
$753k
NCI NIH HHS U01 CA233097NIAMS NIH HHS K08 AR068619NIH HHS DP5 OD021353
6 · The paper itself

Abstract

Immunosuppression increases the risk of cancers that are associated with viral infection

Indexed as

SymbiosisAgedAged, 80 and overAnimalsCarcinogenesisCarcinoma, Squamous CellCD8-Positive T-LymphocytesFemaleHumansImmunocompromised HostMaleMiceMiddle AgedOncogenesPapillomaviridaePapillomavirus InfectionsRNA, Viral

Identifiers

PMID31666702
PMCPMC6872936
OpenAlexW2982312400

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.