Evidence map›Paper›PMID 31666689›Full record

ReviewPediatric research2020

Socioeconomic status and brain injury in children born preterm: modifying neurodevelopmental outcome.

Isabel Benavente-Fernández, Arjumand Siddiqi, Steven P Miller

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Unconditional cash transfers to low-income preterm infants and their families: a pilot randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Trial
  6. Review
  7. Maternal neighborhood deprivation and its association with early childhood neurodevelopmental impairment in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  8. Social & economic neighborhood opportunity as predictors of neurodevelopmental outcomes in high-risk infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Family: a powerful modifier of outcome.Pediatric research · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Isabel Benavente-FernándezDepartment of Pediatrics (Neonatology), University Hospital Puerta del Mar, Avenida Ana de Viya 21, Cádiz, 11009, Spain.
Arjumand SiddiqiDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7, Canada.
Steven P MillerDepartment of Paediatrics (Neurology), The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. steven.miller@sickkids.ca.
Department of Health · ZAHospital for Sick Children · CAHospital Universitario Puerta del Mar · ES

Funding

CIHR
6 · The paper itself

Abstract

Improved intensive care therapies have increased the survival of children born preterm. Yet, many preterm children experience long-term neurodevelopmental sequelae. Indeed, preterm birth remains a leading cause of lifelong neurodevelopmental disability globally, posing significant challenges to the child, family, and society. Neurodevelopmental disability in children born preterm is traditionally linked to acquired brain injuries such as white matter injury and to impaired brain maturation resulting from neonatal illness such as chronic lung disease. Socioeconomic status (SES) has long been recognized to contribute to variation in outcome in children born preterm. Recent brain imaging data in normative term-born cohorts suggest that lower SES itself predicts alterations in brain development, including the growth of the cerebral cortex and subcortical structures. Recent evidence in children born preterm suggests that the response to early-life brain injuries is modified by the socioeconomic circumstances of children and families. Exciting new data points to the potential of more favorable SES circumstances to mitigate the impact of neonatal brain injury. This review addresses emerging evidence suggesting that SES modifies the relationship between early-life exposures, brain injury, and neurodevelopmental outcomes in children born preterm. Better understanding these relationships opens new avenues for research with the ultimate goal of promoting optimal outcomes for those children born preterm at highest risk of neurodevelopmental consequence.

Indexed as

Child BehaviorChild DevelopmentNeurogenesisSocial ClassSocial Determinants of HealthAge FactorsBrain InjuriesChildChild LanguageChild, PreschoolCognitionDevelopmental DisabilitiesHumansInfantInfant, NewbornInfant, Premature

Identifiers

PMID31666689
OpenAlexW2982609994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.