ArticleScientific reports2019
The influences of gender and aging on optic nerve head microcirculation in healthy adults.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Radial Peripapillary Capillary Density Involved in Nasal Optic Disc Thinning and Visual Field Abnormalities Using Optical Coherence Tomography Angiography.Tomography (Ann Arbor, Mich.) · 2026Article
- Machine learning assessment of retinal blood flow links metabolic dysfunction and accelerated microvascular aging.Scientific reports · 2026Article
- The relationship between morphological and functional status and ocular blood flow in retinitis pigmentosa assessed by laser speckle flowgraphy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Beyond the optic disc: Investigating gender-based differences in optic neuritis.World journal of clinical cases · 2025Review
- Multimodal Eye Imaging, Retina Characteristics, and Psychological Assessment Dataset.Scientific data · 2024Article
- Effects of switching from intravitreal injection of aflibercept to faricimab on ocular blood flow in patients with diabetic macular edema.Scientific reports · 2024Article
- Impact of Lipid Parameters on Visual Acuity Change in Non-Arteritic Anterior Ischemic Optic Neuropathy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma.npj aging · 2023Article
- Novel superpixel method to visualize fundus blood flow resistivity in healthy adults.Scientific reports · 2023Article
- Deep Learning Algorithms for Screening and Diagnosis of Systemic Diseases Based on Ophthalmic Manifestations: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Effects of aging and exercise habits on blood flow profile of the ocular circulation.PloS one · 2022Article
- Acute and Chronic Periocular Massage for Ocular Blood Flow and Vision: a Randomized Controlled Trial.International journal of therapeutic massage & bodywork · 2021Article
- Relative Retinal Blood Flow: A Novel and Informative Measure of Unilateral Retinal Vein Occlusion Severity.Translational vision science & technology · 2021Article
- Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model.Scientific reports · 2020Article
- Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation.Dose-response : a publication of International Hormesis SocietyArticle
- Dose-Response Effects of Low-Dose Ionizing Radiation on Blood Parameters in Industrial Irradiation Workers.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
5 authors.
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Abstract
Potential differences in the nature of the influences of aging and gender on the optic nerve head (ONH) microcirculation, using laser speckle flowgraphy (LSFG) were evaluated. We studied 908 healthy subjects (men = 701, age: 50.0 ± 9.1 yrs, women = 208, 49.8 ± 9.5 yrs, p = 0.76). The average, maximum (Max), and minimum (Min) mean blur rate (MBR) in a heartbeat were evaluated. The parameters were analyzed separately for the tissue, vessels, and throughout the ONH (All). We investigated which MBR sections are correlated with gender and age by univariate and multivariate regression analyses. The Max MBR-All (r = -0.31) was most strongly correlated with gender (men = 1, women = 0). The Min MBR-All (r = -0.24) was most strongly correlated with age, followed by Min MBR-All (r = -0.20). The factors contributing independently to the Max MBR-All were gender (β = -0.15), pulse pressure, spherical refraction, ocular perfusion pressure, and red blood cell (RBC) count. The factors contributing independently to the Min MBR-Vessel were gender (β = -0.09), age (β = -0.25), body mass index, heart rate, and spherical refraction. The factors contributing independently to the Min-MBR-All were age (β = -0.22), heart rate, and RBC count. Our results revealed that gender differences influence the Max MBR, and aging influences the Min MBR. These correlations were stronger than that of average MBR.
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