Evidence map›Paper›PMID 31666531›Full record

ArticleScientific reports2019

Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).

Sonja Koch, Lisa Knipfer, Julia Kölle, Hooman Mirzakhani, Anna Graser, Theodor Zimmermann, Alexander Kiefer, Volker O Melichar, Wolfgang Rascher, Nikolaos G Papadopoulos and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. NFATc1 in CD4The journal of allergy and clinical immunology. Global · 2025
    Article
  2. Vitamin DThe journal of allergy and clinical immunology. Global · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. iScience · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Sonja KochDepartment of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Lisa KnipferDepartment of Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Julia KölleDepartment of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Hooman MirzakhaniChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2290-4436
Anna GraserDepartment of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Theodor ZimmermannDepartment of Pediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Erlangen, Germany.
Alexander KieferDepartment of Pediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Erlangen, Germany.
Volker O MelicharDepartment of Pediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0002-8585-2178
Wolfgang RascherDepartment of Pediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Erlangen, Germany.
Nikolaos G PapadopoulosAllergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, 11527, Athens, Greece.ORCID http://orcid.org/0000-0002-4448-3468
Ralf J RiekerInstitute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Benjamin A RabyChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stefan WirtzDepartment of Medicine 1 - Gastroenterology, Pneumology and Endocrinology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Susetta FinottoDepartment of Molecular Pneumology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. susetta.finotto@uk-erlangen.de.ORCID http://orcid.org/0000-0001-7623-7977
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Erlangen · DEBrigham and Women's Hospital · USNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we investigated the role of NFAT-interacting protein (NIP)-45, an Interleukin (IL)-4 inducing Transcription Factor, and its impact on the differentiation of Group 2 Innate -Lymphoid -Cells (ILC2s) in the pathogenesis of asthma. NIP45, a transcription factor regulating NFATc1 activity, mRNA was found to be induced in the Peripheral Blood mononuclear cells (PMBCs) of asthmatic pre-school children with allergies and in the peripheral blood CD4

Indexed as

AnimalsAsthmaCarrier ProteinsChildChild, PreschoolDisease Models, AnimalFemaleHumansImmunity, InnateInterleukin-33Leukocytes, MononuclearLungLymphocytesMaleMiceMice, KnockoutCarrier ProteinsInterleukin-33NFATC1 protein, humanNFATC2IP protein, humanNFATC Transcription FactorsT-bet Transcription FactorT-Box Domain Proteins

Identifiers

PMID31666531
PMCPMC6821848
OpenAlexW2982570959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.