ArticleNature communications2019
The oomycete Lagenisma coscinodisci hijacks host alkaloid synthesis during infection of a marine diatom.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Marine BacteriumJournal of natural products · 2026Article
- Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Rapid adaptive evolution of oxylipin-based chemical defense against algicidal bacteria in a bloom-forming diatom.The ISME journal · 2026Article
- Temperature modulates infection-associated metabolic responses in bloom-forming freshwater diatoms.ISME communications · 2026Article
- Increased Nutrient Levels Enhance Bacterial Exopolysaccharides Production in the Context of Algae.Environmental microbiology reports · 2025Article
- The Impact of Temperature on Host-Parasite Interactions and Metabolomic Profiles in the Marine DiatomPlants (Basel, Switzerland) · 2024Article
- Algal blooms in the ocean: hot spots for chemically mediated microbial interactions.Nature reviews. Microbiology · 2024Review
- Microbial Interactions between Marine Microalgae and Fungi: From Chemical Ecology to Biotechnological Possible Applications.Marine drugs · 2023Review
- Article
- Dynamic Diatom-Bacteria Consortia in Synthetic Plankton Communities.Applied and environmental microbiology · 2022Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flagellated oomycetes frequently infect unicellular algae, thus limiting their proliferation. Here we show that the marine oomycete Lagenisma coscinodisci rewires the metabolome of the bloom-forming diatom Coscinodiscus granii, thereby promoting infection success. The algal alkaloids β-carboline and 4-carboxy-2,3,4,9-tetrahydro-1H-β-carboline are induced during infection. Single-cell profiling with AP-MALDI-MS and confocal laser scanning microscopy reveals that algal carbolines accumulate in the reproductive form of the parasite. The compounds arrest the algal cell division, increase the infection rate and induce plasmolysis in the host. Our results indicate that the oomycete manipulates the host metabolome to support its own multiplication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.