Evidence map›Paper›PMID 31666442›Full record

Observational studyAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2020

Does Preoperative Low HbA1c Predict Esophageal Cancer Outcomes?

Ryosuke Kochi, Takashi Suzuki, Satoshi Yajima, Yoko Oshima, Masaaki Ito, Kimihiko Funahashi, Hideaki Shimada

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryosuke KochiDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Takashi SuzukiDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Satoshi YajimaDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Yoko OshimaDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Masaaki ItoDepartment of Gastroenterological Surgery & Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo, Japan.
Kimihiko FunahashiDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.
Hideaki ShimadaDepartment of Surgery, School of Medicine, Toho University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough several reports have shown that diabetes is a poor prognostic factor for esophageal cancer, no reports assessed prognostic impact of hemoglobin A1c (HbA1c) in the patients with esophageal cancer. Therefore, we evaluated the prognostic significance of HbA1c in patients with esophageal cancer.

methodsA total of 137 patients with esophageal carcinoma surgically treated at our institute between 2009 and 2017 were enrolled in this retrospective study. We divided these patients into quarters according to pretreatment levels of HbA1c. We used 5.5% as a cutoff for classifying patients into low (Q1; n = 30) and high (Q2, Q3, Q4; n = 107) HbA1c groups. Univariate and multivariate analyses were then used to evaluate the clinicopathological and prognostic significance of pretreatment level of HbA1c.

resultsThere was no significant relationship between HbA1c level and clinicopathological factors. The low HbA1c group had a significantly worse survival rate as compared to that of the high HbA1c group (overall survival p = 0.04, relapse-free survival p = 0.02). However, the difference was not confirmed in the multivariate analysis.

conclusionAlthough low level of pretreatment HbA1c might be associated with poor prognosis for patients with esophageal cancer, low HbA1c was not an independent risk factor.

Indexed as

AdultAgedAged, 80 and overBiomarkersDown-RegulationEsophageal NeoplasmsEsophagectomyFemaleGlycated HemoglobinHumansMaleMiddle AgedNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk AssessmentBiomarkersGlycated Hemoglobinhemoglobin A1c protein, humanesophageal cancerHbA1cprognosis

Identifiers

PMID31666442
PMCPMC7435137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.