ArticleScience translational medicine2019
More random motor activity fluctuations predict incident frailty, disability, and mortality.
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Assessing the Temporal Organization of Walking Variability: A Systematic Review and Consensus Guidelines on Detrended Fluctuation Analysis.Frontiers in physiology · 2020Pooled it
- Ageing alters postural sway responsivity to the centre of mass movement.Journal of the Royal Society, Interface · 2025Article
- Angular distribution of fractal temporal correlations supports adaptive responses to wobble board instability.Journal of the Royal Society, Interface · 2025Article
- Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease.Frontiers in aging neuroscience · 2025Article
- Associations of Rest-Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes.Journal of the American Heart Association · 2024Article
- Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data.BMC medical research methodology · 2024Article
- Delineating cognitive resilience using fractal regulation: Cross-sectional and longitudinal evidence from the Rush Memory and Aging Project.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- General spectral characteristics of human activity and its inherent scale-free fluctuations.Scientific reports · 2024Article
- Altered Motor Activity Patterns within 10-Minute Timescale Predict Incident Clinical Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Spatial variability and directional shifts in postural control in Parkinson's disease.Clinical parkinsonism & related disorders · 2024Article
- Frailty detection in older adults via fractal analysis of acceleration signals from wrist-worn sensors.Health information science and systems · 2023Article
- Approaches for assessing circadian rest-activity patterns using actigraphy in cohort and population-based studies.Current sleep medicine reports · 2023Article
- Fractal complexity of daily physical activity and cognitive function in a midlife cohort.Scientific reports · 2023Article
- Circadian disturbances and frailty risk in older adults.Nature communications · 2023Article
- Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data.Research square · 2023Article
- Personalized relapse prediction in patients with major depressive disorder using digital biomarkers.Scientific reports · 2023Article
- Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.Annals of neurology · 2023Article
- Correlates of Person-Specific Rates of Change in Sensor-Derived Physical Activity Metrics of Daily Living in the Rush Memory and Aging Project.Sensors (Basel, Switzerland) · 2023Article
- Differences in Lower Extremity Coordination Patterns as a Function of Sports Specialization.Journal of motor behavior · 2023Article
- Monitoring gait at home with radio waves in Parkinson's disease: A marker of severity, progression, and medication response.Science translational medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Mobile healthcare increasingly relies on analytical tools that can extract meaningful information from ambulatory physiological recordings. We tested whether a nonlinear tool of fractal physiology could predict long-term health consequences in a large, elderly cohort. Fractal physiology is an emerging field that aims to study how fractal temporal structures in physiological fluctuations generated by complex physiological networks can provide important information about system adaptability. We assessed fractal temporal correlations in the spontaneous fluctuations of ambulatory motor activity of 1275 older participants at baseline, with a follow-up period of up to 13 years. We found that people with reduced temporal correlations (more random activity fluctuations) at baseline had increased risk of frailty, disability, and all-cause death during follow-up. Specifically, for 1-SD decrease in the temporal activity correlations of this studied cohort, the risk of frailty increased by 31%, the risk of disability increased by 15 to 25%, and the risk of death increased by 26%. These incidences occurred on average 4.7 years (frailty), 3 to 4.2 years (disability), and 5.8 years (death) after baseline. These observations were independent of age, sex, education, chronic health conditions, depressive symptoms, cognition, motor function, and total daily activity. The temporal structures in daily motor activity fluctuations may contain unique prognostic information regarding wellness and health in the elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.