Evidence map›Paper›PMID 31666318›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions.

Kathleen A Leamy, Ryota Yamagami, Neela H Yennawar, Philip C Bevilacqua

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Structural basis of MALAT1 RNA maturation and mascRNA biogenesis.Nature structural & molecular biology · 2024
    Article
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  5. Genome-wide analysis of theProceedings of the National Academy of Sciences of the United States of America · 2022
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kathleen A LeamyDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802; leamy@gonzaga.edu pcb5@psu.edu.
Ryota YamagamiDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-6947-1906
Neela H YennawarHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802.ORCID 0000-0001-7278-659X
Philip C BevilacquaDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802; leamy@gonzaga.edu pcb5@psu.edu.ORCID 0000-0001-8074-3434
Pennsylvania State University · US

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
RNA Folding and Adaptation in a Cellular ContextR01GM110237 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BEVILACQUA, PHILIP C · 2014 to 2017
$1.1M
NIGMS NIH HHS P30 GM124166NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM110237NIGMS NIH HHS R35 GM127064
6 · The paper itself

Abstract

RNA folding is often studied by renaturing full-length RNA in vitro and tracking folding transitions. However, the intracellular transcript folds as it emerges from the RNA polymerase. Here, we investigate the folding pathways and stability of numerous late-transcriptional intermediates of yeast and

Indexed as

Escherichia coliNucleic Acid ConformationNucleotidesRNA, BacterialRNA FoldingRNA, FungalRNA, TransferYeastsNucleotidesRNA, BacterialRNA, FungalRNA, Transferfolding cooperativityRNA foldingtRNA processing

Identifiers

PMID31666318
PMCPMC6859320
OpenAlexW2982293539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.