ReviewCardiovascular diabetology2019
Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases.
Review in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed, 6 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Selenium supplementation for management of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of randomized controlled trials.BMC endocrine disorders · 2025Pooled it
- Trimester-Specific Serum Lipid Profiles in Gestational Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Influence of maternal diabetes during pregnancy on ultrasound-measured fetal epicardial fat thickness: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Maternal metabolic factors and the association with gestational diabetes: A systematic review and meta-analysis.Diabetes/metabolism research and reviews · 2022Pooled it
- Risk of developing metabolic syndrome after gestational diabetes mellitus - a systematic review and meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis.Endocrine · 2021Pooled it
- The influence of prenatal exercise modes on resting maternal blood lactate.Physiological reports · 2025Trial
- Identification of GPX3 as a key biomarker of placental ferroptosis in gestational diabetes mellitus via bioinformatics and clinical analysis.Molecular diversity · 2026Article
- Development and validation of a multidimensional indicator-based risk prediction model for gestational diabetes mellitus: a nested case-control study.BMC endocrine disorders · 2026Article
- LASSO regression-derived first-trimester (9-14Archives of gynecology and obstetrics · 2026Article
- Untargeted Proteomics Profiling of Liver and Plasma in Fed and Fasted Liver-Specific Glycogen Storage Disease Type Ia (GSD Ia) Mice: Toward Potential Protein Biomarkers.Journal of inherited metabolic disease · 2026Article
- Adiponectin Promotes SHBG Expression in Trophoblast Cells and Improves Insulin Signaling in Streptozotocin-Induced Gestational Diabetes Mellitus Rats.Applied biochemistry and biotechnology · 2026Article
- Association of atherogenic index of plasma and its modified indices with gestational diabetes mellitus: a prospective cohort study based on the Korean population.Frontiers in endocrinology · 2026Article
- Gestational diabetes mellitus-induced adipokine dysregulation and links to metabolic programming risks.Frontiers in endocrinology · 2026Observational
- Exploration of Early Biomarkers for Gestational Diabetes Mellitus in Pregnant Women Living Without Obesity.Journal of diabetes research · 2026Article
- Metabolic biomarkers in early detection of gestational diabetes mellitus: a prospective diagnostic accuracy study.Frontiers in medicine · 2026Article
- Association between prior gestational diabetes mellitus and adverse pregnancy outcomes.Frontiers in endocrinology · 2026Article
- Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism.Journal of diabetes and metabolic disorders · 2025Article
- Maternal liver fibrosis indices as predictors of adverse perinatal outcomes in patients with gestational diabetes mellitus.Acta diabetologica · 2025Article
- Body mass index modifies the association between transthyretin concentrations and gestational diabetes mellitus across pregnancy trimesters.BMC pregnancy and childbirth · 2025Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) is defined as the presence of high blood glucose levels with the onset, or detected for the first time during pregnancy, as a result of increased insulin resistance. GDM may be induced by dysregulation of pancreatic β-cell function and/or by alteration of secreted gestational hormones and peptides related with glucose homeostasis. It may affect one out of five pregnancies, leading to perinatal morbidity and adverse neonatal outcomes, and high risk of chronic metabolic and cardiovascular injuries in both mother and offspring. Currently, GDM diagnosis is based on evaluation of glucose homeostasis at late stages of pregnancy, but increased age and body-weight, and familiar or previous occurrence of GDM, may conditionate this criteria. In addition, an earlier and more specific detection of GDM with associated metabolic and cardiovascular risk could improve GDM development and outcomes. In this sense, 1st-2nd trimester-released biomarkers found in maternal plasma including adipose tissue-derived factors such as adiponectin, visfatin, omentin-1, fatty acid-binding protein-4 and retinol binding-protein-4 have shown correlations with GDM development. Moreover, placenta-related factors such as sex hormone-binding globulin, afamin, fetuin-A, fibroblast growth factors-21/23, ficolin-3 and follistatin, or specific micro-RNAs may participate in GDM progression and be useful for its recognition. Finally, urine-excreted metabolites such as those related with serotonin system, non-polar amino-acids and ketone bodies, may complete a predictive or early-diagnostic panel of biomarkers for GDM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.